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Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer

Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and oth...

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Autores principales: Chung, Chang-Su, Woo, Hyun Sun, Chung, Jun-Won, Jeong, Seok Hoo, Kwon, Kwang An, Kim, Yoon Jae, Kim, Kyoung Oh, Park, Dong Kyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290100/
https://www.ncbi.nlm.nih.gov/pubmed/28145644
http://dx.doi.org/10.3346/jkms.2017.32.3.421
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author Chung, Chang-Su
Woo, Hyun Sun
Chung, Jun-Won
Jeong, Seok Hoo
Kwon, Kwang An
Kim, Yoon Jae
Kim, Kyoung Oh
Park, Dong Kyun
author_facet Chung, Chang-Su
Woo, Hyun Sun
Chung, Jun-Won
Jeong, Seok Hoo
Kwon, Kwang An
Kim, Yoon Jae
Kim, Kyoung Oh
Park, Dong Kyun
author_sort Chung, Chang-Su
collection PubMed
description Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and other risk factors for recurrence. We aimed to compare the metachronous lesion in the H. pylori persistent group and the eradicated group, and to identify risk factors for metachronous lesion. We retrospectively analyzed 782 patients who underwent ESD between January 2008 and December 2013. We excluded patients with dysplasia or patients who were not tested for H. pylori infection. One hundred eighty-five patients were enrolled. We studied risk factors for recurrence, and used survival analysis to test. There were 24 patients with metachronous recurrence after ESD for EGC among the group. The incidence of metachronous gastric lesions after ESD for EGC developed more in the over 70-year-old group (P = 0.025) and more in the H. pylori persistent group (P = 0.008). In conclusion, H. pylori infection and old age are independent risk factors for metachronous gastric lesions after ESD in EGC.
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spelling pubmed-52901002017-03-01 Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer Chung, Chang-Su Woo, Hyun Sun Chung, Jun-Won Jeong, Seok Hoo Kwon, Kwang An Kim, Yoon Jae Kim, Kyoung Oh Park, Dong Kyun J Korean Med Sci Original Article Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and other risk factors for recurrence. We aimed to compare the metachronous lesion in the H. pylori persistent group and the eradicated group, and to identify risk factors for metachronous lesion. We retrospectively analyzed 782 patients who underwent ESD between January 2008 and December 2013. We excluded patients with dysplasia or patients who were not tested for H. pylori infection. One hundred eighty-five patients were enrolled. We studied risk factors for recurrence, and used survival analysis to test. There were 24 patients with metachronous recurrence after ESD for EGC among the group. The incidence of metachronous gastric lesions after ESD for EGC developed more in the over 70-year-old group (P = 0.025) and more in the H. pylori persistent group (P = 0.008). In conclusion, H. pylori infection and old age are independent risk factors for metachronous gastric lesions after ESD in EGC. The Korean Academy of Medical Sciences 2017-03 2017-01-10 /pmc/articles/PMC5290100/ /pubmed/28145644 http://dx.doi.org/10.3346/jkms.2017.32.3.421 Text en © 2017 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Chang-Su
Woo, Hyun Sun
Chung, Jun-Won
Jeong, Seok Hoo
Kwon, Kwang An
Kim, Yoon Jae
Kim, Kyoung Oh
Park, Dong Kyun
Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title_full Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title_fullStr Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title_full_unstemmed Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title_short Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
title_sort risk factors for metachronous recurrence after endoscopic submucosal dissection of early gastric cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290100/
https://www.ncbi.nlm.nih.gov/pubmed/28145644
http://dx.doi.org/10.3346/jkms.2017.32.3.421
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