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Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer
Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and oth...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290100/ https://www.ncbi.nlm.nih.gov/pubmed/28145644 http://dx.doi.org/10.3346/jkms.2017.32.3.421 |
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author | Chung, Chang-Su Woo, Hyun Sun Chung, Jun-Won Jeong, Seok Hoo Kwon, Kwang An Kim, Yoon Jae Kim, Kyoung Oh Park, Dong Kyun |
author_facet | Chung, Chang-Su Woo, Hyun Sun Chung, Jun-Won Jeong, Seok Hoo Kwon, Kwang An Kim, Yoon Jae Kim, Kyoung Oh Park, Dong Kyun |
author_sort | Chung, Chang-Su |
collection | PubMed |
description | Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and other risk factors for recurrence. We aimed to compare the metachronous lesion in the H. pylori persistent group and the eradicated group, and to identify risk factors for metachronous lesion. We retrospectively analyzed 782 patients who underwent ESD between January 2008 and December 2013. We excluded patients with dysplasia or patients who were not tested for H. pylori infection. One hundred eighty-five patients were enrolled. We studied risk factors for recurrence, and used survival analysis to test. There were 24 patients with metachronous recurrence after ESD for EGC among the group. The incidence of metachronous gastric lesions after ESD for EGC developed more in the over 70-year-old group (P = 0.025) and more in the H. pylori persistent group (P = 0.008). In conclusion, H. pylori infection and old age are independent risk factors for metachronous gastric lesions after ESD in EGC. |
format | Online Article Text |
id | pubmed-5290100 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-52901002017-03-01 Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer Chung, Chang-Su Woo, Hyun Sun Chung, Jun-Won Jeong, Seok Hoo Kwon, Kwang An Kim, Yoon Jae Kim, Kyoung Oh Park, Dong Kyun J Korean Med Sci Original Article Although endoscopic submucosal dissection (ESD) is widely accepted as a curative treatment method for early gastric cancer (EGC) worldwide, metachronous recurrence often occurs after ESD for EGC. However, there are insufficient data about the role of Helicobacter pylori (H. pylori) infection and other risk factors for recurrence. We aimed to compare the metachronous lesion in the H. pylori persistent group and the eradicated group, and to identify risk factors for metachronous lesion. We retrospectively analyzed 782 patients who underwent ESD between January 2008 and December 2013. We excluded patients with dysplasia or patients who were not tested for H. pylori infection. One hundred eighty-five patients were enrolled. We studied risk factors for recurrence, and used survival analysis to test. There were 24 patients with metachronous recurrence after ESD for EGC among the group. The incidence of metachronous gastric lesions after ESD for EGC developed more in the over 70-year-old group (P = 0.025) and more in the H. pylori persistent group (P = 0.008). In conclusion, H. pylori infection and old age are independent risk factors for metachronous gastric lesions after ESD in EGC. The Korean Academy of Medical Sciences 2017-03 2017-01-10 /pmc/articles/PMC5290100/ /pubmed/28145644 http://dx.doi.org/10.3346/jkms.2017.32.3.421 Text en © 2017 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Chang-Su Woo, Hyun Sun Chung, Jun-Won Jeong, Seok Hoo Kwon, Kwang An Kim, Yoon Jae Kim, Kyoung Oh Park, Dong Kyun Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title | Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title_full | Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title_fullStr | Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title_full_unstemmed | Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title_short | Risk Factors for Metachronous Recurrence after Endoscopic Submucosal Dissection of Early Gastric Cancer |
title_sort | risk factors for metachronous recurrence after endoscopic submucosal dissection of early gastric cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290100/ https://www.ncbi.nlm.nih.gov/pubmed/28145644 http://dx.doi.org/10.3346/jkms.2017.32.3.421 |
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