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Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis
Multiple sclerosis is a demyelinating disease affecting the central nervous system. T cells are known to contribute to this immune-mediated condition. Fingolimod modulates sphingosine-1-phosphate receptors, thereby preventing the egress of lymphocytes, especially CCR7-expressing CD8+ and CD4+ T cell...
Autores principales: | Friess, Jörg, Hecker, Michael, Roch, Luisa, Koczan, Dirk, Fitzner, Brit, Angerer, Ines Charlotte, Schröder, Ina, Flechtner, Kristin, Thiesen, Hans-Jürgen, Winkelmann, Alexander, Zettl, Uwe Klaus |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290459/ https://www.ncbi.nlm.nih.gov/pubmed/28155899 http://dx.doi.org/10.1038/srep42087 |
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