Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms un...

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Detalles Bibliográficos
Autores principales: Tu, Zhuchi, Yang, Weili, Yan, Sen, Yin, An, Gao, Jinquan, Liu, Xudong, Zheng, Yinghui, Zheng, Jiezhao, Li, Zhujun, Yang, Su, Li, Shihua, Guo, Xiangyu, Li, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290468/
https://www.ncbi.nlm.nih.gov/pubmed/28155910
http://dx.doi.org/10.1038/srep42081

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