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Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

BACKGROUND: It is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can significantly impact the transcriptome. However, it...

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Detalles Bibliográficos
Autores principales:	Li, Ya-feng, Nanayakkara, Gayani, Sun, Yu, Li, Xinyuan, Wang, Luqiao, Cueto, Ramon, Shao, Ying, Fu, Hangfei, Johnson, Candice, Cheng, Jiali, Chen, Xiongwen, Hu, Wenhui, Yu, Jun, Choi, Eric T., Wang, Hong, Yang, Xiao-feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290602/ https://www.ncbi.nlm.nih.gov/pubmed/28153032 http://dx.doi.org/10.1186/s13045-017-0406-2

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