Toxic metabolites, MAPK and Nrf2/Keap1 signaling pathways involved in oxidative toxicity in mice liver after chronic exposure to Mequindox

Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of...

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Detalles Bibliográficos
Autores principales: Liu, Qianying, Lei, Zhixin, Huang, Anxiong, Wu, Qinghua, Xie, Shuyu, Awais, Ihsan, Dai, Menghong, Wang, Xu, Yuan, Zonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291092/
https://www.ncbi.nlm.nih.gov/pubmed/28157180
http://dx.doi.org/10.1038/srep41854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291092/
https://www.ncbi.nlm.nih.gov/pubmed/28157180
http://dx.doi.org/10.1038/srep41854

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