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Molecular mutagenesis of ppGpp: turning a RelA activator into an inhibitor

The alarmone nucleotide (p)ppGpp is a key regulator of bacterial metabolism, growth, stress tolerance and virulence, making (p)ppGpp-mediated signaling a promising target for development of antibacterials. Although ppGpp itself is an activator of the ribosome-associated ppGpp synthetase RelA, severa...

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Detalles Bibliográficos
Autores principales:	Beljantseva, Jelena, Kudrin, Pavel, Jimmy, Steffi, Ehn, Marcel, Pohl, Radek, Varik, Vallo, Tozawa, Yuzuru, Shingler, Victoria, Tenson, Tanel, Rejman, Dominik, Hauryliuk, Vasili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291098/ https://www.ncbi.nlm.nih.gov/pubmed/28157202 http://dx.doi.org/10.1038/srep41839

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