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Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014

Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surve...

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Autores principales: Sheppard, Carmen, Fry, Norman K., Mushtaq, Shazad, Woodford, Neil, Reynolds, Rosy, Janes, Regina, Pike, Rachel, Hill, Robert, Kimuli, Maimuna, Staves, Peter, Doumith, Michel, Harrison, Timothy, Livermore, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291132/
https://www.ncbi.nlm.nih.gov/pubmed/28006650
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.50.30423
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author Sheppard, Carmen
Fry, Norman K.
Mushtaq, Shazad
Woodford, Neil
Reynolds, Rosy
Janes, Regina
Pike, Rachel
Hill, Robert
Kimuli, Maimuna
Staves, Peter
Doumith, Michel
Harrison, Timothy
Livermore, David M
author_facet Sheppard, Carmen
Fry, Norman K.
Mushtaq, Shazad
Woodford, Neil
Reynolds, Rosy
Janes, Regina
Pike, Rachel
Hill, Robert
Kimuli, Maimuna
Staves, Peter
Doumith, Michel
Harrison, Timothy
Livermore, David M
author_sort Sheppard, Carmen
collection PubMed
description Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001–2014; (ii) Public Health England’s (PHE) invasive isolate surveillance from 2005–2014 and (iii) referral to PHE for resistance investigation from 2005–2014. Serotype 15A increased in all series, with many representatives showing triple resistance to macrolides, tetracyclines and penicillin. 15A was consistently among the 10 most prevalent serotypes from 2011 in PHE and BSAC invasive isolate/bacteraemia surveillance but never previously; 26–33% of these invasive 15A isolates had triple resistance. BSAC respiratory isolates were only serotyped in 2013/14 and 2014/15 (October to September); 15A was most prevalent serotype in both periods, comprising 9–11% of isolates, 38–48% of them with triple resistance. Serotype 15A represented 0–4% of S. pneumoniae referred to PHE for reference investigation annually until 2008 but rose to 29% (2013) and 32% (2014). Almost all multidrug-resistant 15A isolates were sequence type (ST) 63 variants, whereas susceptible 15A isolates were clonally diverse. The rise of serotype 15A suggests that pneumococcal conjugate vaccines will need ongoing adaptation.
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spelling pubmed-52911322017-02-06 Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014 Sheppard, Carmen Fry, Norman K. Mushtaq, Shazad Woodford, Neil Reynolds, Rosy Janes, Regina Pike, Rachel Hill, Robert Kimuli, Maimuna Staves, Peter Doumith, Michel Harrison, Timothy Livermore, David M Euro Surveill Research Article Conjugate vaccines have reduced pneumococcal disease in vaccinated children and unvaccinated adults, but non-vaccine serotypes are of concern, particularly if antibiotic resistant. We reviewed Streptococcus pneumoniae collected via: (i) the British Society for Antimicrobial Chemotherapy (BSAC) surveillances from 2001–2014; (ii) Public Health England’s (PHE) invasive isolate surveillance from 2005–2014 and (iii) referral to PHE for resistance investigation from 2005–2014. Serotype 15A increased in all series, with many representatives showing triple resistance to macrolides, tetracyclines and penicillin. 15A was consistently among the 10 most prevalent serotypes from 2011 in PHE and BSAC invasive isolate/bacteraemia surveillance but never previously; 26–33% of these invasive 15A isolates had triple resistance. BSAC respiratory isolates were only serotyped in 2013/14 and 2014/15 (October to September); 15A was most prevalent serotype in both periods, comprising 9–11% of isolates, 38–48% of them with triple resistance. Serotype 15A represented 0–4% of S. pneumoniae referred to PHE for reference investigation annually until 2008 but rose to 29% (2013) and 32% (2014). Almost all multidrug-resistant 15A isolates were sequence type (ST) 63 variants, whereas susceptible 15A isolates were clonally diverse. The rise of serotype 15A suggests that pneumococcal conjugate vaccines will need ongoing adaptation. European Centre for Disease Prevention and Control (ECDC) 2016-12-15 /pmc/articles/PMC5291132/ /pubmed/28006650 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.50.30423 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Sheppard, Carmen
Fry, Norman K.
Mushtaq, Shazad
Woodford, Neil
Reynolds, Rosy
Janes, Regina
Pike, Rachel
Hill, Robert
Kimuli, Maimuna
Staves, Peter
Doumith, Michel
Harrison, Timothy
Livermore, David M
Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title_full Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title_fullStr Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title_full_unstemmed Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title_short Rise of multidrug-resistant non-vaccine serotype 15A Streptococcus pneumoniae in the United Kingdom, 2001 to 2014
title_sort rise of multidrug-resistant non-vaccine serotype 15a streptococcus pneumoniae in the united kingdom, 2001 to 2014
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291132/
https://www.ncbi.nlm.nih.gov/pubmed/28006650
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.50.30423
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