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Trivalent inactivated influenza vaccine effective against influenza A(H3N2) variant viruses in children during the 2014/15 season, Japan

The 2014/15 influenza season in Japan was characterised by predominant influenza A(H3N2) activity; 99% of influenza A viruses detected were A(H3N2). Subclade 3C.2a viruses were the major epidemic A(H3N2) viruses, and were genetically distinct from A/New York/39/2012(H3N2) of 2014/15 vaccine strain i...

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Detalles Bibliográficos
Autores principales: Sugaya, Norio, Shinjoh, Masayoshi, Kawakami, Chiharu, Yamaguchi, Yoshio, Yoshida, Makoto, Baba, Hiroaki, Ishikawa, Mayumi, Kono, Mio, Sekiguchi, Shinichiro, Kimiya, Takahisa, Mitamura, Keiko, Fujino, Motoko, Komiyama, Osamu, Yoshida, Naoko, Tsunematsu, Kenichiro, Narabayashi, Atsushi, Nakata, Yuji, Sato, Akihiro, Taguchi, Nobuhiko, Fujita, Hisayo, Toki, Machiko, Myokai, Michiko, Ookawara, Ichiro, Takahashi, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291153/
https://www.ncbi.nlm.nih.gov/pubmed/27784529
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.42.30377
Descripción
Sumario:The 2014/15 influenza season in Japan was characterised by predominant influenza A(H3N2) activity; 99% of influenza A viruses detected were A(H3N2). Subclade 3C.2a viruses were the major epidemic A(H3N2) viruses, and were genetically distinct from A/New York/39/2012(H3N2) of 2014/15 vaccine strain in Japan, which was classified as clade 3C.1. We assessed vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children aged 6 months to 15 years by test-negative case–control design based on influenza rapid diagnostic test. Between November 2014 and March 2015, a total of 3,752 children were enrolled: 1,633 tested positive for influenza A and 42 for influenza B, and 2,077 tested negative. Adjusted VE was 38% (95% confidence intervals (CI): 28 to 46) against influenza virus infection overall, 37% (95% CI: 27 to 45) against influenza A, and 47% (95% CI: -2 to 73) against influenza B. However, IIV was not statistically significantly effective against influenza A in infants aged 6 to 11 months or adolescents aged 13 to 15 years. VE in preventing hospitalisation for influenza A infection was 55% (95% CI: 42 to 64). Trivalent IIV that included A/New York/39/2012(H3N2) was effective against drifted influenza A(H3N2) virus, although vaccine mismatch resulted in low VE.