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Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies

Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Control...

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Autores principales: Mertz, Dominik, Fadel, Shaza A., Lam, Po-Po, Tran, Dat, Srigley, Jocelyn A, Asner, Sandra A, Science, Michelle, Kuster, Stefan P, Nemeth, Johannes, Johnstone, Jennie, Ortiz, Justin R, Loeb, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291154/
https://www.ncbi.nlm.nih.gov/pubmed/27784531
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.42.30378
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author Mertz, Dominik
Fadel, Shaza A.
Lam, Po-Po
Tran, Dat
Srigley, Jocelyn A
Asner, Sandra A
Science, Michelle
Kuster, Stefan P
Nemeth, Johannes
Johnstone, Jennie
Ortiz, Justin R
Loeb, Mark
author_facet Mertz, Dominik
Fadel, Shaza A.
Lam, Po-Po
Tran, Dat
Srigley, Jocelyn A
Asner, Sandra A
Science, Michelle
Kuster, Stefan P
Nemeth, Johannes
Johnstone, Jennie
Ortiz, Justin R
Loeb, Mark
author_sort Mertz, Dominik
collection PubMed
description Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34–1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26–0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43–0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved.
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spelling pubmed-52911542017-02-06 Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies Mertz, Dominik Fadel, Shaza A. Lam, Po-Po Tran, Dat Srigley, Jocelyn A Asner, Sandra A Science, Michelle Kuster, Stefan P Nemeth, Johannes Johnstone, Jennie Ortiz, Justin R Loeb, Mark Euro Surveill Systematic Review Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34–1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26–0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43–0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved. European Centre for Disease Prevention and Control (ECDC) 2016-10-20 /pmc/articles/PMC5291154/ /pubmed/27784531 http://dx.doi.org/10.2807/1560-7917.ES.2016.21.42.30378 Text en This article is copyright of The Authors, 2016. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Systematic Review
Mertz, Dominik
Fadel, Shaza A.
Lam, Po-Po
Tran, Dat
Srigley, Jocelyn A
Asner, Sandra A
Science, Michelle
Kuster, Stefan P
Nemeth, Johannes
Johnstone, Jennie
Ortiz, Justin R
Loeb, Mark
Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title_full Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title_fullStr Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title_full_unstemmed Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title_short Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
title_sort herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291154/
https://www.ncbi.nlm.nih.gov/pubmed/27784531
http://dx.doi.org/10.2807/1560-7917.ES.2016.21.42.30378
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