The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

Aggregation of TAR-DNA-binding protein 43 (TDP-43) and of its fragments TDP-25 and TDP-35 occurs in amyotrophic lateral sclerosis (ALS). TDP-25 and TDP-35 act as seeds for TDP-43 aggregation, altering its function and exerting toxicity. Thus, inhibition of TDP-25 and TDP-35 aggregation and promotion...

Descripción completa

Detalles Bibliográficos
Autores principales: Crippa, Valeria, Cicardi, Maria Elena, Ramesh, Nandini, Seguin, Samuel J., Ganassi, Massimo, Bigi, Ilaria, Diacci, Chiara, Zelotti, Elena, Baratashvili, Madina, Gregory, Jenna M., Dobson, Christopher M., Cereda, Cristina, Pandey, Udai Bhan, Poletti, Angelo, Carra, Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291228/
https://www.ncbi.nlm.nih.gov/pubmed/27466192
http://dx.doi.org/10.1093/hmg/ddw232

Ejemplares similares

Ejemplares similares