G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase

Certain guanine-rich sequences have an inherent propensity to form G-quadruplex (G4) structures. G4 structures are e.g. involved in telomere protection and gene regulation. However, they also constitute obstacles during replication if they remain unresolved. To overcome these threats to genome integ...

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Detalles Bibliográficos
Autores principales: Wallgren, Marcus, Mohammad, Jani B., Yan, Kok-Phen, Pourbozorgi-Langroudi, Parham, Ebrahimi, Mahsa, Sabouri, Nasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291255/
https://www.ncbi.nlm.nih.gov/pubmed/27185885
http://dx.doi.org/10.1093/nar/gkw349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291255/
https://www.ncbi.nlm.nih.gov/pubmed/27185885
http://dx.doi.org/10.1093/nar/gkw349

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