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Mapping DNA polymerase errors by single-molecule sequencing
Genomic integrity is compromised by DNA polymerase replication errors, which occur in a sequence-dependent manner across the genome. Accurate and complete quantification of a DNA polymerase's error spectrum is challenging because errors are rare and difficult to detect. We report a high-through...
Autores principales: | Lee, David F., Lu, Jenny, Chang, Seungwoo, Loparo, Joseph J., Xie, Xiaoliang S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291262/ https://www.ncbi.nlm.nih.gov/pubmed/27185891 http://dx.doi.org/10.1093/nar/gkw436 |
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