Cargando…

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduced in the absence of either IL-6 or IL-21. The aim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roeleveld, Debbie M., Marijnissen, Renoud J., Walgreen, Birgitte, Helsen, Monique M., van den Bersselaar, Liduine, van de Loo, Fons A., van Lent, Peter L., van der Kraan, Peter M., van den Berg, Wim B., Koenders, Marije I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291406/ https://www.ncbi.nlm.nih.gov/pubmed/28158305 http://dx.doi.org/10.1371/journal.pone.0171757

Ejemplares similares

Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
por: van Nieuwenhuijze, Annemarie E. M., et al.
Publicado: (2015)

Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis
por: Aarts, Joyce, et al.
Publicado: (2022)

Alteration of the intestinal microbiome characterizes preclinical inflammatory arthritis in mice and its modulation attenuates established arthritis
por: Rogier, Rebecca, et al.
Publicado: (2017)

Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice
por: Aarts, Joyce, et al.
Publicado: (2020)

Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice
por: Rogier, Rebecca, et al.
Publicado: (2019)

Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice
por: Rogier, Rebecca, et al.
Publicado: (2019)

IL-1β-Mediated Activation of Adipose-Derived Mesenchymal Stromal Cells Results in PMN Reallocation and Enhanced Phagocytosis: A Possible Mechanism for the Reduction of Osteoarthritis Pathology
por: van Dalen, Stephanie C. M., et al.
Publicado: (2019)

Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
por: Joosten, LAB, et al.
Publicado: (2005)

Early pain in females is linked to late pathological features in murine experimental osteoarthritis
por: Valdrighi, Natália, et al.
Publicado: (2023)

Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis
por: de Munter, Wouter, et al.
Publicado: (2013)

Systemic Resolvin E1 (RvE1) Treatment Does Not Ameliorate the Severity of Collagen-Induced Arthritis (CIA) in Mice: A Randomized, Prospective, and Controlled Proof of Concept Study
por: de Molon, Rafael Scaf, et al.
Publicado: (2019)

Nox2 Deficiency Reduces Cartilage Damage and Ectopic Bone Formation in an Experimental Model for Osteoarthritis
por: Kruisbergen, Nik N. L., et al.
Publicado: (2021)

Innate Immunity and Sex: Distinct Inflammatory Profiles Associated with Murine Pain in Acute Synovitis
por: Valdrighi, Natália, et al.
Publicado: (2023)

Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis
por: Waterborg, Claire E. J., et al.
Publicado: (2018)

TNF-α dependency of IL-17-induced joint pathology differs under naive and arthritis conditions in vivo
por: Koenders, M, et al.
Publicado: (2003)

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis
por: Di Ceglie, Irene, et al.
Publicado: (2018)

TNF dependency of IL-17-induced joint pathology can be circumvented by Toll-like receptor-2 signaling
por: Van den Berg, W, et al.
Publicado: (2003)

IL-18 directly promotes joint inflammation and induces cartilage destruction through IL-1
por: Joosten, L, et al.
Publicado: (2003)

An optimized method for plasma extracellular vesicles isolation to exclude the copresence of biological drugs and plasma proteins which impairs their biological characterization
por: Arntz, Onno J., et al.
Publicado: (2020)

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
por: Waterborg, Claire E. J., et al.
Publicado: (2018)

Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region
por: Thielen, Nathalie, et al.
Publicado: (2021)

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation
por: Broeren, Mathijs G.A., et al.
Publicado: (2018)

Fibroblast Activation Protein Targeted Photodynamic Therapy Selectively Kills Activated Skin Fibroblasts from Systemic Sclerosis Patients and Prevents Tissue Contraction
por: Dorst, Daphne N., et al.
Publicado: (2021)

The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis
por: Blom, Arjen B., et al.
Publicado: (2020)

Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane
por: Broeren, Mathijs G. A., et al.
Publicado: (2016)

Photodynamic Therapy Targeting Macrophages Using IRDye700DX-Liposomes Decreases Experimental Arthritis Development
por: Dorst, Daphne N., et al.
Publicado: (2021)

Targeted photodynamic therapy selectively kills activated fibroblasts in experimental arthritis
por: Dorst, Daphne N, et al.
Publicado: (2020)

Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis
por: Rogier, Rebecca, et al.
Publicado: (2017)

Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis
por: Lubberts, E, et al.
Publicado: (2004)

Exposure to Candida albicans Polarizes a T-Cell Driven Arthritis Model towards Th17 Responses, Resulting in a More Destructive Arthritis
por: Marijnissen, Renoud J., et al.
Publicado: (2012)

Rheumatoid Arthritis Patients With Circulating Extracellular Vesicles Positive for IgM Rheumatoid Factor Have Higher Disease Activity
por: Arntz, Onno J., et al.
Publicado: (2018)

Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
por: Davidson, Esmeralda N Blaney, et al.
Publicado: (2007)

IL-1-driven cartilage and bone destruction are dependent on Toll-like receptor (TLR) 4, but not TLR2
por: Abdollahi-Roodsaz, S, et al.
Publicado: (2005)

Targeting of fibroblast activation protein in rheumatoid arthritis patients: imaging and ex vivo photodynamic therapy
por: Dorst, Daphne N, et al.
Publicado: (2021)

IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα
por: Joosten, LAB, et al.
Publicado: (2002)

Commercial Cow Milk Contains Physically Stable Extracellular Vesicles Expressing Immunoregulatory TGF-β
por: Pieters, Bartijn C. H., et al.
Publicado: (2015)

Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium
por: Broeren, Mathijs G. A., et al.
Publicado: (2016)

Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis
por: Vullings, Julia, et al.
Publicado: (2020)

The In-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis
por: Vermeij, Eline A., et al.
Publicado: (2015)

Disease-Dependent Local IL-10 Production Ameliorates Collagen Induced Arthritis in Mice
por: Henningsson, Louise, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hohk7onpanu89cbq959r3o8rfc