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Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduced in the absence of either IL-6 or IL-21. The aim...

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Detalles Bibliográficos
Autores principales:	Roeleveld, Debbie M., Marijnissen, Renoud J., Walgreen, Birgitte, Helsen, Monique M., van den Bersselaar, Liduine, van de Loo, Fons A., van Lent, Peter L., van der Kraan, Peter M., van den Berg, Wim B., Koenders, Marije I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291406/ https://www.ncbi.nlm.nih.gov/pubmed/28158305 http://dx.doi.org/10.1371/journal.pone.0171757

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