Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives

In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodi...

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Detalles Bibliográficos
Autores principales: Sidova, Veronika, Zoufaly, Pavel, Pokorny, Jan, Dzubak, Petr, Hajduch, Marian, Popa, Igor, Urban, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291411/
https://www.ncbi.nlm.nih.gov/pubmed/28158265
http://dx.doi.org/10.1371/journal.pone.0171621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291411/
https://www.ncbi.nlm.nih.gov/pubmed/28158265
http://dx.doi.org/10.1371/journal.pone.0171621

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