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Cytotoxic conjugates of betulinic acid and substituted triazoles prepared by Huisgen Cycloaddition from 30-azidoderivatives

In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodi...

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Detalles Bibliográficos
Autores principales:	Sidova, Veronika, Zoufaly, Pavel, Pokorny, Jan, Dzubak, Petr, Hajduch, Marian, Popa, Igor, Urban, Milan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291411/ https://www.ncbi.nlm.nih.gov/pubmed/28158265 http://dx.doi.org/10.1371/journal.pone.0171621

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