Cargando…
Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed:...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291459/ https://www.ncbi.nlm.nih.gov/pubmed/28184152 http://dx.doi.org/10.2147/DDDT.S100075 |
_version_ | 1782504784337567744 |
---|---|
author | Marianecci, Carlotta Rinaldi, Federica Hanieh, Patrizia Nadia Di Marzio, Luisa Paolino, Donatella Carafa, Maria |
author_facet | Marianecci, Carlotta Rinaldi, Federica Hanieh, Patrizia Nadia Di Marzio, Luisa Paolino, Donatella Carafa, Maria |
author_sort | Marianecci, Carlotta |
collection | PubMed |
description | The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques. Preliminary results, reported in the large number of studies on the potential strategies for brain delivery, are encouraging, but it is far too early to draw any conclusion about the actual use of these therapeutic approaches. Among the most recent, but still pioneering, approaches related to the nasal mucosa properties, the permeabilization of the BBB via nasal mucosal engrafting can offer new potential opportunities. It should be emphasized that this surgical procedure is quite invasive, but the implication for patient outcome needs to be compared to the gold standard of direct intracranial injection, and evaluated whilst keeping in mind that central nervous system diseases and lysosomal storage diseases are chronic and severely debilitating and that up to now no therapy seems to be completely successful. |
format | Online Article Text |
id | pubmed-5291459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52914592017-02-09 Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting Marianecci, Carlotta Rinaldi, Federica Hanieh, Patrizia Nadia Di Marzio, Luisa Paolino, Donatella Carafa, Maria Drug Des Devel Ther Review The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross the BBB, many strategies have been developed: invasive techniques, such as temporary disruption of the BBB or direct intraventricular and intracerebral administration of the drug, as well as noninvasive techniques. Preliminary results, reported in the large number of studies on the potential strategies for brain delivery, are encouraging, but it is far too early to draw any conclusion about the actual use of these therapeutic approaches. Among the most recent, but still pioneering, approaches related to the nasal mucosa properties, the permeabilization of the BBB via nasal mucosal engrafting can offer new potential opportunities. It should be emphasized that this surgical procedure is quite invasive, but the implication for patient outcome needs to be compared to the gold standard of direct intracranial injection, and evaluated whilst keeping in mind that central nervous system diseases and lysosomal storage diseases are chronic and severely debilitating and that up to now no therapy seems to be completely successful. Dove Medical Press 2017-01-27 /pmc/articles/PMC5291459/ /pubmed/28184152 http://dx.doi.org/10.2147/DDDT.S100075 Text en © 2017 Marianecci et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Marianecci, Carlotta Rinaldi, Federica Hanieh, Patrizia Nadia Di Marzio, Luisa Paolino, Donatella Carafa, Maria Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title | Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title_full | Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title_fullStr | Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title_full_unstemmed | Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title_short | Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
title_sort | drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291459/ https://www.ncbi.nlm.nih.gov/pubmed/28184152 http://dx.doi.org/10.2147/DDDT.S100075 |
work_keys_str_mv | AT marianeccicarlotta drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting AT rinaldifederica drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting AT haniehpatrizianadia drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting AT dimarzioluisa drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting AT paolinodonatella drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting AT carafamaria drugdeliveryinovercomingthebloodbrainbarrierroleofnasalmucosalgrafting |