Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay

Phosphorylated H2AX (γ-H2AX) is a sensitive marker for DNA double-strand breaks (DSBs), but the variability of H2AX expression in different cell and tissue types makes it difficult to interpret the meaning of the γ-H2AX level. Furthermore, the assays commonly used for γ-H2AX detection utilize labori...

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Detalles Bibliográficos
Autores principales: Ji, Jiuping, Zhang, Yiping, Redon, Christophe E., Reinhold, William C., Chen, Alice P., Fogli, Laura K., Holbeck, Susan L., Parchment, Ralph E., Hollingshead, Melinda, Tomaszewski, Joseph E., Dudon, Quentin, Pommier, Yves, Doroshow, James H., Bonner, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291513/
https://www.ncbi.nlm.nih.gov/pubmed/28158293
http://dx.doi.org/10.1371/journal.pone.0171582

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