Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1

Post-translational modifications of histone play important roles in gene transcription. Aberrant methylation of histone lysine sidechains have been often found in cancer. Lysine specific demethylase 1 (LSD1), which can demethylate histone H3 lysine 4 (H3K4) and other proteins, has recently been foun...

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Detalles Bibliográficos
Autores principales: Zhou, Chao, Wu, Fangrui, Lu, Lianghao, Wei, Liping, Pai, Eric, Yao, Yuan, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291514/
https://www.ncbi.nlm.nih.gov/pubmed/28158205
http://dx.doi.org/10.1371/journal.pone.0170301

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