Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study

Only a few studies provided data on the clinical history of sepsis within internal Medicine units. The aim of the study was to assess the short-term mortality and to evaluate the prognostic risk factors in a large cohort of septic patients treated in internal medicine units. Thirty-one internal medi...

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Autores principales: Mazzone, Antonino, Dentali, Francesco, La Regina, Micaela, Foglia, Emanuela, Gambacorta, Maurizia, Garagiola, Elisabetta, Bonardi, Giorgio, Clerici, Pierangelo, Concia, Ercole, Colombo, Fabrizio, Campanini, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291546/
https://www.ncbi.nlm.nih.gov/pubmed/26825876
http://dx.doi.org/10.1097/MD.0000000000002124
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author Mazzone, Antonino
Dentali, Francesco
La Regina, Micaela
Foglia, Emanuela
Gambacorta, Maurizia
Garagiola, Elisabetta
Bonardi, Giorgio
Clerici, Pierangelo
Concia, Ercole
Colombo, Fabrizio
Campanini, Mauro
author_facet Mazzone, Antonino
Dentali, Francesco
La Regina, Micaela
Foglia, Emanuela
Gambacorta, Maurizia
Garagiola, Elisabetta
Bonardi, Giorgio
Clerici, Pierangelo
Concia, Ercole
Colombo, Fabrizio
Campanini, Mauro
author_sort Mazzone, Antonino
collection PubMed
description Only a few studies provided data on the clinical history of sepsis within internal Medicine units. The aim of the study was to assess the short-term mortality and to evaluate the prognostic risk factors in a large cohort of septic patients treated in internal medicine units. Thirty-one internal medicine units participated to the study. Within each participating unit, all admitted patients were screened for the presence of sepsis. A total of 533 patients were included; 78 patients (14.6%, 95%CI 11.9, 18.0%) died during hospitalization; mortality rate was 5.5% (95% CI 3.1, 9.6%) in patients with nonsevere sepsis and 20.1% (95%CI 16.2, 28.8%) in patients with severe sepsis or septic shock. Severe sepsis or septic shock (OR 4.41, 95%CI 1.93, 10.05), immune system weakening (OR 2.10, 95%CI 1.12, 3.94), active solid cancer (OR 2.14, 95% CI 1.16, 3.94), and age (OR 1.03 per year, 95% CI 1.01, 1.06) were significantly associated with an increased mortality risk, whereas blood culture positive for Escherichia coli was significantly associated with a reduced mortality risk (OR 0.46, 95%CI 0.24, 0.88). In-hospital mortality of septic patients treated in internal medicine units appeared similar to the mortality rate obtained in recent studies conducted in the ICU setting.
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spelling pubmed-52915462017-02-09 Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study Mazzone, Antonino Dentali, Francesco La Regina, Micaela Foglia, Emanuela Gambacorta, Maurizia Garagiola, Elisabetta Bonardi, Giorgio Clerici, Pierangelo Concia, Ercole Colombo, Fabrizio Campanini, Mauro Medicine (Baltimore) 4900 Only a few studies provided data on the clinical history of sepsis within internal Medicine units. The aim of the study was to assess the short-term mortality and to evaluate the prognostic risk factors in a large cohort of septic patients treated in internal medicine units. Thirty-one internal medicine units participated to the study. Within each participating unit, all admitted patients were screened for the presence of sepsis. A total of 533 patients were included; 78 patients (14.6%, 95%CI 11.9, 18.0%) died during hospitalization; mortality rate was 5.5% (95% CI 3.1, 9.6%) in patients with nonsevere sepsis and 20.1% (95%CI 16.2, 28.8%) in patients with severe sepsis or septic shock. Severe sepsis or septic shock (OR 4.41, 95%CI 1.93, 10.05), immune system weakening (OR 2.10, 95%CI 1.12, 3.94), active solid cancer (OR 2.14, 95% CI 1.16, 3.94), and age (OR 1.03 per year, 95% CI 1.01, 1.06) were significantly associated with an increased mortality risk, whereas blood culture positive for Escherichia coli was significantly associated with a reduced mortality risk (OR 0.46, 95%CI 0.24, 0.88). In-hospital mortality of septic patients treated in internal medicine units appeared similar to the mortality rate obtained in recent studies conducted in the ICU setting. Wolters Kluwer Health 2016-01-29 /pmc/articles/PMC5291546/ /pubmed/26825876 http://dx.doi.org/10.1097/MD.0000000000002124 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4900
Mazzone, Antonino
Dentali, Francesco
La Regina, Micaela
Foglia, Emanuela
Gambacorta, Maurizia
Garagiola, Elisabetta
Bonardi, Giorgio
Clerici, Pierangelo
Concia, Ercole
Colombo, Fabrizio
Campanini, Mauro
Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title_full Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title_fullStr Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title_full_unstemmed Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title_short Clinical Features, Short-Term Mortality, and Prognostic Risk Factors of Septic Patients Admitted to Internal Medicine Units: Results of an Italian Multicenter Prospective Study
title_sort clinical features, short-term mortality, and prognostic risk factors of septic patients admitted to internal medicine units: results of an italian multicenter prospective study
topic 4900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291546/
https://www.ncbi.nlm.nih.gov/pubmed/26825876
http://dx.doi.org/10.1097/MD.0000000000002124
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