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Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review

Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was...

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Autores principales: Liu, Min, Liu, Shixin, Liu, Bailong, Liu, Bin, Guo, Liang, Wang, Xu, Wang, Qiang, Yang, Shuo, Dong, Lihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291591/
https://www.ncbi.nlm.nih.gov/pubmed/26825921
http://dx.doi.org/10.1097/MD.0000000000002632
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author Liu, Min
Liu, Shixin
Liu, Bailong
Liu, Bin
Guo, Liang
Wang, Xu
Wang, Qiang
Yang, Shuo
Dong, Lihua
author_facet Liu, Min
Liu, Shixin
Liu, Bailong
Liu, Bin
Guo, Liang
Wang, Xu
Wang, Qiang
Yang, Shuo
Dong, Lihua
author_sort Liu, Min
collection PubMed
description Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure. After radiotherapy (27 Gy, 9 fractions), the patient experienced relief from his pain, and the cranial nerve dysfunction regressed. However, the patient ultimately died, due to the tumor's progression. Radiotherapy is usually the best option to relieve pain and achieve regression of cranial nerve dysfunction in cases of SBM from HCC, although early treatment is needed to achieve optimal outcomes. The present case helps expand our understanding regarding this rare metastatic pathway and indicates that improved awareness of SBM in clinical practice can help facilitate timely and appropriate treatment.
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spelling pubmed-52915912017-02-09 Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review Liu, Min Liu, Shixin Liu, Bailong Liu, Bin Guo, Liang Wang, Xu Wang, Qiang Yang, Shuo Dong, Lihua Medicine (Baltimore) 5700 Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure. After radiotherapy (27 Gy, 9 fractions), the patient experienced relief from his pain, and the cranial nerve dysfunction regressed. However, the patient ultimately died, due to the tumor's progression. Radiotherapy is usually the best option to relieve pain and achieve regression of cranial nerve dysfunction in cases of SBM from HCC, although early treatment is needed to achieve optimal outcomes. The present case helps expand our understanding regarding this rare metastatic pathway and indicates that improved awareness of SBM in clinical practice can help facilitate timely and appropriate treatment. Wolters Kluwer Health 2016-01-29 /pmc/articles/PMC5291591/ /pubmed/26825921 http://dx.doi.org/10.1097/MD.0000000000002632 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0
spellingShingle 5700
Liu, Min
Liu, Shixin
Liu, Bailong
Liu, Bin
Guo, Liang
Wang, Xu
Wang, Qiang
Yang, Shuo
Dong, Lihua
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title_full Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title_fullStr Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title_full_unstemmed Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title_short Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
title_sort bulbar paralysis and facial paralysis due to metastatic hepatocellular carcinoma: a case report and literature review
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291591/
https://www.ncbi.nlm.nih.gov/pubmed/26825921
http://dx.doi.org/10.1097/MD.0000000000002632
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