Cargando…
Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review
Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291591/ https://www.ncbi.nlm.nih.gov/pubmed/26825921 http://dx.doi.org/10.1097/MD.0000000000002632 |
_version_ | 1782504808991686656 |
---|---|
author | Liu, Min Liu, Shixin Liu, Bailong Liu, Bin Guo, Liang Wang, Xu Wang, Qiang Yang, Shuo Dong, Lihua |
author_facet | Liu, Min Liu, Shixin Liu, Bailong Liu, Bin Guo, Liang Wang, Xu Wang, Qiang Yang, Shuo Dong, Lihua |
author_sort | Liu, Min |
collection | PubMed |
description | Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure. After radiotherapy (27 Gy, 9 fractions), the patient experienced relief from his pain, and the cranial nerve dysfunction regressed. However, the patient ultimately died, due to the tumor's progression. Radiotherapy is usually the best option to relieve pain and achieve regression of cranial nerve dysfunction in cases of SBM from HCC, although early treatment is needed to achieve optimal outcomes. The present case helps expand our understanding regarding this rare metastatic pathway and indicates that improved awareness of SBM in clinical practice can help facilitate timely and appropriate treatment. |
format | Online Article Text |
id | pubmed-5291591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52915912017-02-09 Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review Liu, Min Liu, Shixin Liu, Bailong Liu, Bin Guo, Liang Wang, Xu Wang, Qiang Yang, Shuo Dong, Lihua Medicine (Baltimore) 5700 Skull-base metastasis (SBM) from hepatocellular carcinoma (HCC) is extremely rare, and multiple cranial nerve paralysis due to SBM from HCC is also rare. We report a case of bulbar and facial paralysis due to SBM from HCC. A 46-year-old Chinese man presented with a hepatic right lobe lesion that was detected during a routine physical examination. After several failed attempts to treat the primary tumor and bone metastases, neurological examination revealed left VII, IX, X, and XI cranial nerve paralysis. Computed tomography of the skull base subsequently revealed a large mass that had destroyed the left occipital and temporal bones and invaded the adjacent structure. After radiotherapy (27 Gy, 9 fractions), the patient experienced relief from his pain, and the cranial nerve dysfunction regressed. However, the patient ultimately died, due to the tumor's progression. Radiotherapy is usually the best option to relieve pain and achieve regression of cranial nerve dysfunction in cases of SBM from HCC, although early treatment is needed to achieve optimal outcomes. The present case helps expand our understanding regarding this rare metastatic pathway and indicates that improved awareness of SBM in clinical practice can help facilitate timely and appropriate treatment. Wolters Kluwer Health 2016-01-29 /pmc/articles/PMC5291591/ /pubmed/26825921 http://dx.doi.org/10.1097/MD.0000000000002632 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0 |
spellingShingle | 5700 Liu, Min Liu, Shixin Liu, Bailong Liu, Bin Guo, Liang Wang, Xu Wang, Qiang Yang, Shuo Dong, Lihua Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title | Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title_full | Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title_fullStr | Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title_full_unstemmed | Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title_short | Bulbar Paralysis and Facial Paralysis due to Metastatic Hepatocellular Carcinoma: A Case Report and Literature Review |
title_sort | bulbar paralysis and facial paralysis due to metastatic hepatocellular carcinoma: a case report and literature review |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291591/ https://www.ncbi.nlm.nih.gov/pubmed/26825921 http://dx.doi.org/10.1097/MD.0000000000002632 |
work_keys_str_mv | AT liumin bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT liushixin bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT liubailong bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT liubin bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT guoliang bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT wangxu bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT wangqiang bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT yangshuo bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview AT donglihua bulbarparalysisandfacialparalysisduetometastatichepatocellularcarcinomaacasereportandliteraturereview |