Cargando…

Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity

The purpose of our study was to retrospectively evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for postoperative surveillance of lung adenocarcinoma manifesting as ground-glass opacity (GGO). From May 2003 to December 2007, 111 patients w...

Descripción completa

Detalles Bibliográficos
Autores principales: Nam, Kyung Bum, Kim, Tae Jung, Park, Jeong-Soo, Chung, Myung Jin, Lee, Kyung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291592/
https://www.ncbi.nlm.nih.gov/pubmed/26825922
http://dx.doi.org/10.1097/MD.0000000000002634
_version_ 1782504809209790464
author Nam, Kyung Bum
Kim, Tae Jung
Park, Jeong-Soo
Chung, Myung Jin
Lee, Kyung Won
author_facet Nam, Kyung Bum
Kim, Tae Jung
Park, Jeong-Soo
Chung, Myung Jin
Lee, Kyung Won
author_sort Nam, Kyung Bum
collection PubMed
description The purpose of our study was to retrospectively evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for postoperative surveillance of lung adenocarcinoma manifesting as ground-glass opacity (GGO). From May 2003 to December 2007, 111 patients with surgically resected lung adenocarcinoma manifesting as GGO were included. Clinical findings of recurrence and survival, CT features, and maximum standardized uptake value (SUVmax) were reviewed and compared among 3 groups according to GGO proportion: Group I, GGO 100%; Group II, GGO ≥50%; Group III, GGO < 50%. Disease-free survival (DFS) was estimated using the Kaplan–Meier method. Diagnostic performances of CT and PET/CT for recurrence were compared during a long-term follow-up period of >5 years. Recurrence was identified in Group III (18 of 53, 34%) but not in Groups I (n = 25) or II (n = 33) over a mean follow-up period of 74 months. Group showed significant differences in GGO proportion, SUVmax, and DFS duration (P < 0.001). PET/CT led to 6 false-positive and 5 false-negative interpretations of recurrence. For surveillance CT, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 94.4%, 98.6%, 98.2%, 94.4%, and 98.9%, respectively; for PET/CT, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 72.2%, 92.3%, 88.5%, 68.4%, and 93.5%, respectively. CT showed significantly higher accuracy than PET/CT (P = 0.0188). FDG-PET/CT showed no clear advantage for postoperative surveillance of lung cancer with predominant GGO because of low incidence of recurrence and frequent false-positive and false-negative results.
format Online
Article
Text
id pubmed-5291592
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-52915922017-02-09 Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity Nam, Kyung Bum Kim, Tae Jung Park, Jeong-Soo Chung, Myung Jin Lee, Kyung Won Medicine (Baltimore) 6800 The purpose of our study was to retrospectively evaluate the value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for postoperative surveillance of lung adenocarcinoma manifesting as ground-glass opacity (GGO). From May 2003 to December 2007, 111 patients with surgically resected lung adenocarcinoma manifesting as GGO were included. Clinical findings of recurrence and survival, CT features, and maximum standardized uptake value (SUVmax) were reviewed and compared among 3 groups according to GGO proportion: Group I, GGO 100%; Group II, GGO ≥50%; Group III, GGO < 50%. Disease-free survival (DFS) was estimated using the Kaplan–Meier method. Diagnostic performances of CT and PET/CT for recurrence were compared during a long-term follow-up period of >5 years. Recurrence was identified in Group III (18 of 53, 34%) but not in Groups I (n = 25) or II (n = 33) over a mean follow-up period of 74 months. Group showed significant differences in GGO proportion, SUVmax, and DFS duration (P < 0.001). PET/CT led to 6 false-positive and 5 false-negative interpretations of recurrence. For surveillance CT, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 94.4%, 98.6%, 98.2%, 94.4%, and 98.9%, respectively; for PET/CT, sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 72.2%, 92.3%, 88.5%, 68.4%, and 93.5%, respectively. CT showed significantly higher accuracy than PET/CT (P = 0.0188). FDG-PET/CT showed no clear advantage for postoperative surveillance of lung cancer with predominant GGO because of low incidence of recurrence and frequent false-positive and false-negative results. Wolters Kluwer Health 2016-01-29 /pmc/articles/PMC5291592/ /pubmed/26825922 http://dx.doi.org/10.1097/MD.0000000000002634 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 6800
Nam, Kyung Bum
Kim, Tae Jung
Park, Jeong-Soo
Chung, Myung Jin
Lee, Kyung Won
Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title_full Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title_fullStr Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title_full_unstemmed Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title_short Long-Term Follow-Up Results From PET/CT Surveillance After Surgical Resection of Lung Adenocarcinoma Manifesting as Ground-Glass Opacity
title_sort long-term follow-up results from pet/ct surveillance after surgical resection of lung adenocarcinoma manifesting as ground-glass opacity
topic 6800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291592/
https://www.ncbi.nlm.nih.gov/pubmed/26825922
http://dx.doi.org/10.1097/MD.0000000000002634
work_keys_str_mv AT namkyungbum longtermfollowupresultsfrompetctsurveillanceaftersurgicalresectionoflungadenocarcinomamanifestingasgroundglassopacity
AT kimtaejung longtermfollowupresultsfrompetctsurveillanceaftersurgicalresectionoflungadenocarcinomamanifestingasgroundglassopacity
AT parkjeongsoo longtermfollowupresultsfrompetctsurveillanceaftersurgicalresectionoflungadenocarcinomamanifestingasgroundglassopacity
AT chungmyungjin longtermfollowupresultsfrompetctsurveillanceaftersurgicalresectionoflungadenocarcinomamanifestingasgroundglassopacity
AT leekyungwon longtermfollowupresultsfrompetctsurveillanceaftersurgicalresectionoflungadenocarcinomamanifestingasgroundglassopacity