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APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article

To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging. Seventy-six healthy adults (34 men, 23.7 ± 2.8 y; 31 APOE ε4/ε3 carriers...

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Autores principales: Su, Yun Yan, Liang, Xue, Schoepf, U. Joseph, Varga-Szemes, Akos, West, Henry C., Qi, Rongfeng, Kong, Xiang, Chen, Hui Juan, Lu, Guang Ming, Zhang, Long Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291594/
https://www.ncbi.nlm.nih.gov/pubmed/26717353
http://dx.doi.org/10.1097/MD.0000000000001734
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author Su, Yun Yan
Liang, Xue
Schoepf, U. Joseph
Varga-Szemes, Akos
West, Henry C.
Qi, Rongfeng
Kong, Xiang
Chen, Hui Juan
Lu, Guang Ming
Zhang, Long Jiang
author_facet Su, Yun Yan
Liang, Xue
Schoepf, U. Joseph
Varga-Szemes, Akos
West, Henry C.
Qi, Rongfeng
Kong, Xiang
Chen, Hui Juan
Lu, Guang Ming
Zhang, Long Jiang
author_sort Su, Yun Yan
collection PubMed
description To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging. Seventy-six healthy adults (34 men, 23.7 ± 2.8 y; 31 APOE ε4/ε3 carriers, 31 ε3/ε3 carriers, and 14 ε2/ε3 carriers) were included. For resting-state functional MRI data, default mode network (DMN) and amplitude of low-frequency fluctuation maps were extracted and analyzed. Voxel-based morphometry, diffusion tensor imaging from structural imaging, and cerebral blood flow based on arterial spin labeling MR imaging were also analyzed. Correlation analysis was performed between the above mentioned brain parameters and neuropsychological tests. There were no differences in neuropsychological performances, amplitude of low-frequency fluctuation, gray/white matter volumes, fractional anisotropy, mean diffusivity, or whole brain cerebral blood flow among the 3 groups. As for DMN, the ε4/ε3 group showed increased functional connectivities (FCs) in the left medial prefrontal cortex and bilateral posterior cingulate cortices/precuneus compared with the ε3/ε3 group, and increased FCs in the left medial prefrontal cortex and right temporal lobe compared with the ε2/ε3 group (P < 0.05, Alphasim corrected). No differences of DMN FCs were found between the ε2/ε3 and ε3/ε3 groups. FCs in the right temporal lobe positively correlated with the performances of vocabulary learning, delayed recall, and graph recall in all participants (P < 0.05). APOE ε4 carriers exhibited significantly increased DMN FCs when compared with ε3 and ε2 carriers. The ε4 affects DMN FCs before brain structure and blood flow in cognitively intact young patients, suggesting DMN FC may serve as a potential biomarker for the detection of early manifestations of genetic effect.
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spelling pubmed-52915942017-02-09 APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article Su, Yun Yan Liang, Xue Schoepf, U. Joseph Varga-Szemes, Akos West, Henry C. Qi, Rongfeng Kong, Xiang Chen, Hui Juan Lu, Guang Ming Zhang, Long Jiang Medicine (Baltimore) 5300 To investigate the effect of apolipoprotein E (APOE) gene polymorphism on the resting-state brain function, structure, and blood flow in healthy adults younger than 35 years, using multimodality magnetic resonance (MR) imaging. Seventy-six healthy adults (34 men, 23.7 ± 2.8 y; 31 APOE ε4/ε3 carriers, 31 ε3/ε3 carriers, and 14 ε2/ε3 carriers) were included. For resting-state functional MRI data, default mode network (DMN) and amplitude of low-frequency fluctuation maps were extracted and analyzed. Voxel-based morphometry, diffusion tensor imaging from structural imaging, and cerebral blood flow based on arterial spin labeling MR imaging were also analyzed. Correlation analysis was performed between the above mentioned brain parameters and neuropsychological tests. There were no differences in neuropsychological performances, amplitude of low-frequency fluctuation, gray/white matter volumes, fractional anisotropy, mean diffusivity, or whole brain cerebral blood flow among the 3 groups. As for DMN, the ε4/ε3 group showed increased functional connectivities (FCs) in the left medial prefrontal cortex and bilateral posterior cingulate cortices/precuneus compared with the ε3/ε3 group, and increased FCs in the left medial prefrontal cortex and right temporal lobe compared with the ε2/ε3 group (P < 0.05, Alphasim corrected). No differences of DMN FCs were found between the ε2/ε3 and ε3/ε3 groups. FCs in the right temporal lobe positively correlated with the performances of vocabulary learning, delayed recall, and graph recall in all participants (P < 0.05). APOE ε4 carriers exhibited significantly increased DMN FCs when compared with ε3 and ε2 carriers. The ε4 affects DMN FCs before brain structure and blood flow in cognitively intact young patients, suggesting DMN FC may serve as a potential biomarker for the detection of early manifestations of genetic effect. Wolters Kluwer Health 2015-12-31 /pmc/articles/PMC5291594/ /pubmed/26717353 http://dx.doi.org/10.1097/MD.0000000000001734 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5300
Su, Yun Yan
Liang, Xue
Schoepf, U. Joseph
Varga-Szemes, Akos
West, Henry C.
Qi, Rongfeng
Kong, Xiang
Chen, Hui Juan
Lu, Guang Ming
Zhang, Long Jiang
APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title_full APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title_fullStr APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title_full_unstemmed APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title_short APOE Polymorphism Affects Brain Default Mode Network in Healthy Young Adults: A STROBE Article
title_sort apoe polymorphism affects brain default mode network in healthy young adults: a strobe article
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291594/
https://www.ncbi.nlm.nih.gov/pubmed/26717353
http://dx.doi.org/10.1097/MD.0000000000001734
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