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Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015
Influenza B viral infection is of great importance, but the epidemiological and phylogenetic characteristics of influenza B infection in severe acute respiratory infection (SARI) cases are still unclear. The clinical information of 2816 SARI cases and 467,737 influenza-like illness (ILI) cases in Be...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291634/ https://www.ncbi.nlm.nih.gov/pubmed/26717393 http://dx.doi.org/10.1097/MD.0000000000002399 |
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author | Pan, Yang Zhang, Yi Yang, Peng Qian, Haiqun Shi, Weixian Wu, Shuangsheng Cui, Shujuan Zhang, Daitao Wang, Quanyi |
author_facet | Pan, Yang Zhang, Yi Yang, Peng Qian, Haiqun Shi, Weixian Wu, Shuangsheng Cui, Shujuan Zhang, Daitao Wang, Quanyi |
author_sort | Pan, Yang |
collection | PubMed |
description | Influenza B viral infection is of great importance, but the epidemiological and phylogenetic characteristics of influenza B infection in severe acute respiratory infection (SARI) cases are still unclear. The clinical information of 2816 SARI cases and 467,737 influenza-like illness (ILI) cases in Beijing area from September 2014 to April 2015 were collected and analyzed. Among them, 91 influenza B viruses isolated from SARI cases were sequenced. The overall yield rate of influenza A/B infection was 14.21% and 27.77% in sampled SARI and ILI cases, respectively. Compared with influenza A infection, the frequency of influenza B infection in SARI cases was higher in younger patients. Phylogenetic analysis suggested that most tested hemagglutination genes belonged to Yamagata lineage Clade 3, which were similar with current circulating viruses but different with 2014 to 2015 influenza season vaccine strain (Clade 2). Importantly, HA-Y3/NA-V4 intralineage reassorting was identified in Beijing area for the first time, which can act as a possible risk factor of SARIs. The influenza activity and virus types/subtypes/lineages among SARI patients were well correlated with that of ILI cases. Furthermore, the potential risk of reassorted influenza B virus infection should not be overlooked. |
format | Online Article Text |
id | pubmed-5291634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-52916342017-02-09 Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 Pan, Yang Zhang, Yi Yang, Peng Qian, Haiqun Shi, Weixian Wu, Shuangsheng Cui, Shujuan Zhang, Daitao Wang, Quanyi Medicine (Baltimore) 4900 Influenza B viral infection is of great importance, but the epidemiological and phylogenetic characteristics of influenza B infection in severe acute respiratory infection (SARI) cases are still unclear. The clinical information of 2816 SARI cases and 467,737 influenza-like illness (ILI) cases in Beijing area from September 2014 to April 2015 were collected and analyzed. Among them, 91 influenza B viruses isolated from SARI cases were sequenced. The overall yield rate of influenza A/B infection was 14.21% and 27.77% in sampled SARI and ILI cases, respectively. Compared with influenza A infection, the frequency of influenza B infection in SARI cases was higher in younger patients. Phylogenetic analysis suggested that most tested hemagglutination genes belonged to Yamagata lineage Clade 3, which were similar with current circulating viruses but different with 2014 to 2015 influenza season vaccine strain (Clade 2). Importantly, HA-Y3/NA-V4 intralineage reassorting was identified in Beijing area for the first time, which can act as a possible risk factor of SARIs. The influenza activity and virus types/subtypes/lineages among SARI patients were well correlated with that of ILI cases. Furthermore, the potential risk of reassorted influenza B virus infection should not be overlooked. Wolters Kluwer Health 2015-12-31 /pmc/articles/PMC5291634/ /pubmed/26717393 http://dx.doi.org/10.1097/MD.0000000000002399 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial License, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 4900 Pan, Yang Zhang, Yi Yang, Peng Qian, Haiqun Shi, Weixian Wu, Shuangsheng Cui, Shujuan Zhang, Daitao Wang, Quanyi Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title | Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title_full | Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title_fullStr | Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title_full_unstemmed | Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title_short | Epidemiological and Phylogenetic Characteristics of Influenza B Infection in Severe Acute Respiratory Infection Cases in Beijing, 2014 to 2015 |
title_sort | epidemiological and phylogenetic characteristics of influenza b infection in severe acute respiratory infection cases in beijing, 2014 to 2015 |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291634/ https://www.ncbi.nlm.nih.gov/pubmed/26717393 http://dx.doi.org/10.1097/MD.0000000000002399 |
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