Structure of the active form of human origin recognition complex and its ATPase motor module

Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. Here, we report the structure of the active form of human ORC determined by X-ray crystallography and cryo-electron microscopy. The c...

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Detalles Bibliográficos
Autores principales: Tocilj, Ante, On, Kin Fan, Yuan, Zuanning, Sun, Jingchuan, Elkayam, Elad, Li, Huilin, Stillman, Bruce, Joshua-Tor, Leemor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291709/
https://www.ncbi.nlm.nih.gov/pubmed/28112645
http://dx.doi.org/10.7554/eLife.20818

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