Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen

Mixed hepatitis C virus (HCV) genotype infection is emerging with improved methods of detection. It is commonly seen in hemodialysis patients and intravenous drug users due to repeated HCV exposure and absence of protective immunity, and can contribute to treatment failure. Direct-acting antiviral r...

Descripción completa

Detalles Bibliográficos
Autores principales: Ahmed Sakr, Ayman, Hanifi, Jasmine M., Valerie Lin, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Gastroenterology 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291715/
https://www.ncbi.nlm.nih.gov/pubmed/28184373
http://dx.doi.org/10.14309/crj.2017.16
_version_ 1782504826290044928
author Ahmed Sakr, Ayman
Hanifi, Jasmine M.
Valerie Lin, Ming
author_facet Ahmed Sakr, Ayman
Hanifi, Jasmine M.
Valerie Lin, Ming
author_sort Ahmed Sakr, Ayman
collection PubMed
description Mixed hepatitis C virus (HCV) genotype infection is emerging with improved methods of detection. It is commonly seen in hemodialysis patients and intravenous drug users due to repeated HCV exposure and absence of protective immunity, and can contribute to treatment failure. Direct-acting antiviral regimens have been extensively studied in patients with different individual HCV genotypes; however, there are no reported data on their use in patients with mixed HCV genotype. We present a case of mixed HCV genotype 1a and 2 infection in a decompensated cirrhotic patient treated successfully with sofosbuvir, ledipasvir, and ribavirin.
format Online
Article
Text
id pubmed-5291715
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher American College of Gastroenterology
record_format MEDLINE/PubMed
spelling pubmed-52917152017-02-09 Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen Ahmed Sakr, Ayman Hanifi, Jasmine M. Valerie Lin, Ming ACG Case Rep J Case Report Mixed hepatitis C virus (HCV) genotype infection is emerging with improved methods of detection. It is commonly seen in hemodialysis patients and intravenous drug users due to repeated HCV exposure and absence of protective immunity, and can contribute to treatment failure. Direct-acting antiviral regimens have been extensively studied in patients with different individual HCV genotypes; however, there are no reported data on their use in patients with mixed HCV genotype. We present a case of mixed HCV genotype 1a and 2 infection in a decompensated cirrhotic patient treated successfully with sofosbuvir, ledipasvir, and ribavirin. American College of Gastroenterology 2017-02-01 /pmc/articles/PMC5291715/ /pubmed/28184373 http://dx.doi.org/10.14309/crj.2017.16 Text en Copyright © Ahmed Sakr et al. This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Case Report
Ahmed Sakr, Ayman
Hanifi, Jasmine M.
Valerie Lin, Ming
Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title_full Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title_fullStr Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title_full_unstemmed Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title_short Successful Treatment of Mixed Hepatitis C Genotypes in a Cirrhotic Patient With an All-Oral, Interferon-Free Regimen
title_sort successful treatment of mixed hepatitis c genotypes in a cirrhotic patient with an all-oral, interferon-free regimen
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291715/
https://www.ncbi.nlm.nih.gov/pubmed/28184373
http://dx.doi.org/10.14309/crj.2017.16
work_keys_str_mv AT ahmedsakrayman successfultreatmentofmixedhepatitiscgenotypesinacirrhoticpatientwithanalloralinterferonfreeregimen
AT hanifijasminem successfultreatmentofmixedhepatitiscgenotypesinacirrhoticpatientwithanalloralinterferonfreeregimen
AT valerielinming successfultreatmentofmixedhepatitiscgenotypesinacirrhoticpatientwithanalloralinterferonfreeregimen

Ejemplares similares