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Consanguinity Among Parents of Iranian Deaf Children

BACKGROUND: It seems that there is a relationship between consanguinity and profound hearing loss but there is little data about the association of consanguinity and hearing loss in Iran. OBJECTIVES: The aim of this study is to demonstrate the causes of profound bilateral sensorineural hearing loss...

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Autores principales: Ajallouyan, Mohammad, Radfar, Shokofeh, Nouhi, Sima, Tavallaie, Seid Abbas, Amirsalari, Susan, Yousefi, Jaleh, Hasanali Fard, Mahdieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292111/
https://www.ncbi.nlm.nih.gov/pubmed/28191326
http://dx.doi.org/10.5812/ircmj.22038
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author Ajallouyan, Mohammad
Radfar, Shokofeh
Nouhi, Sima
Tavallaie, Seid Abbas
Amirsalari, Susan
Yousefi, Jaleh
Hasanali Fard, Mahdieh
author_facet Ajallouyan, Mohammad
Radfar, Shokofeh
Nouhi, Sima
Tavallaie, Seid Abbas
Amirsalari, Susan
Yousefi, Jaleh
Hasanali Fard, Mahdieh
author_sort Ajallouyan, Mohammad
collection PubMed
description BACKGROUND: It seems that there is a relationship between consanguinity and profound hearing loss but there is little data about the association of consanguinity and hearing loss in Iran. OBJECTIVES: The aim of this study is to demonstrate the causes of profound bilateral sensorineural hearing loss among Iranian samples who are candidates for cochlear implantation. METHODS: This study was retrospective, analytical, and designed to collect information about profound hearing impaired cases referred to the Baqiyatallah Cochlear implantation center using enumeration. A total of 310 children with profound hearing impairments participated in this study. They were aged from 6 months to 4 years old. The study was done between January 2007 and April 2009. Chi-square tests were used to show whether there was any statistical difference between the incidence of marital consanguinity of their parents and the normal population. RESULTS: Sixty-five percent of those 310 children had parents who had married with their relatives. Of the 203 (65%) parents that had consanguineous marriages, 132 were first cousins, which includes the children of two brothers (37 [11.8%] patrilateral parallel cousins), the children of two sisters (38 [12.2%] multi-lateral parallel cousins), or the children of a brother and a sister (57 [18.3%] cross cousins). Fifty-four (17.4%) of the parents were second cousins and 17 (5.2%) were beyond second cousins. Also, hearing loss etiology was obvious in 237 (76.3%) of the patients with profound hearing loss but was unknown in 73 (23.7%). Hereditary was identified as the most common cause in 33% of the cases. CONCLUSIONS: Our data demonstrated a 65% occurrence of consanguineous marriage among the parents of deaf children, which is statistically different from the percentage of consanguineous marriage among Iranian population (38%). This indicates an obvious relationship between severe hearing loss and consanguineous marriage.
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spelling pubmed-52921112017-02-10 Consanguinity Among Parents of Iranian Deaf Children Ajallouyan, Mohammad Radfar, Shokofeh Nouhi, Sima Tavallaie, Seid Abbas Amirsalari, Susan Yousefi, Jaleh Hasanali Fard, Mahdieh Iran Red Crescent Med J Research Article BACKGROUND: It seems that there is a relationship between consanguinity and profound hearing loss but there is little data about the association of consanguinity and hearing loss in Iran. OBJECTIVES: The aim of this study is to demonstrate the causes of profound bilateral sensorineural hearing loss among Iranian samples who are candidates for cochlear implantation. METHODS: This study was retrospective, analytical, and designed to collect information about profound hearing impaired cases referred to the Baqiyatallah Cochlear implantation center using enumeration. A total of 310 children with profound hearing impairments participated in this study. They were aged from 6 months to 4 years old. The study was done between January 2007 and April 2009. Chi-square tests were used to show whether there was any statistical difference between the incidence of marital consanguinity of their parents and the normal population. RESULTS: Sixty-five percent of those 310 children had parents who had married with their relatives. Of the 203 (65%) parents that had consanguineous marriages, 132 were first cousins, which includes the children of two brothers (37 [11.8%] patrilateral parallel cousins), the children of two sisters (38 [12.2%] multi-lateral parallel cousins), or the children of a brother and a sister (57 [18.3%] cross cousins). Fifty-four (17.4%) of the parents were second cousins and 17 (5.2%) were beyond second cousins. Also, hearing loss etiology was obvious in 237 (76.3%) of the patients with profound hearing loss but was unknown in 73 (23.7%). Hereditary was identified as the most common cause in 33% of the cases. CONCLUSIONS: Our data demonstrated a 65% occurrence of consanguineous marriage among the parents of deaf children, which is statistically different from the percentage of consanguineous marriage among Iranian population (38%). This indicates an obvious relationship between severe hearing loss and consanguineous marriage. Kowsar 2016-08-07 /pmc/articles/PMC5292111/ /pubmed/28191326 http://dx.doi.org/10.5812/ircmj.22038 Text en Copyright © 2016, Iranian Red Crescent Medical Journal http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Ajallouyan, Mohammad
Radfar, Shokofeh
Nouhi, Sima
Tavallaie, Seid Abbas
Amirsalari, Susan
Yousefi, Jaleh
Hasanali Fard, Mahdieh
Consanguinity Among Parents of Iranian Deaf Children
title Consanguinity Among Parents of Iranian Deaf Children
title_full Consanguinity Among Parents of Iranian Deaf Children
title_fullStr Consanguinity Among Parents of Iranian Deaf Children
title_full_unstemmed Consanguinity Among Parents of Iranian Deaf Children
title_short Consanguinity Among Parents of Iranian Deaf Children
title_sort consanguinity among parents of iranian deaf children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292111/
https://www.ncbi.nlm.nih.gov/pubmed/28191326
http://dx.doi.org/10.5812/ircmj.22038
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