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Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population
BACKGROUND: There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS). OBJECTIVES: The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Irania...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292135/ https://www.ncbi.nlm.nih.gov/pubmed/28191332 http://dx.doi.org/10.5812/ircmj.23942 |
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author | Delshad, Navid Ghayour-Mobarhan, Majid Mirzaei, Hamed Razavi-Azarkhiavi, Kamal Moohebati, Mohsen Hassany, Mitra Kasaian, Jamal Etemadzadeh, Mohammad Reza Alavi, Maryam Sadat Behravan, Javad |
author_facet | Delshad, Navid Ghayour-Mobarhan, Majid Mirzaei, Hamed Razavi-Azarkhiavi, Kamal Moohebati, Mohsen Hassany, Mitra Kasaian, Jamal Etemadzadeh, Mohammad Reza Alavi, Maryam Sadat Behravan, Javad |
author_sort | Delshad, Navid |
collection | PubMed |
description | BACKGROUND: There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS). OBJECTIVES: The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population. PATIENTS AND METHODS: This cross-sectional study was conducted among 263 subjects (97 men and 166 women). Patients (n = 128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran). A 12-lead electrocardiograph plus creatine kinase MB (CK-MB) levels were used as the basis for the diagnosis of myocardial ischemia. The control group was selected from age-matched healthy subjects (n = 135). Non-enzymatic kits were used for extraction of DNA from blood samples. Polymerase chain reaction (PCR) was performed to amplify the DNA fragments. For restriction fragment length polymorphism (RFLP) determination, the DdeI enzyme was used to digest the amplified DNA fragments. Statistical analyses were performed using SPSS version 13.0. RESULTS: There was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (P > 0.05). CONCLUSIONS: The AT1R A1166C polymorphism appeared not to be associated with the presence of ACS in the population studied. |
format | Online Article Text |
id | pubmed-5292135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-52921352017-02-10 Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population Delshad, Navid Ghayour-Mobarhan, Majid Mirzaei, Hamed Razavi-Azarkhiavi, Kamal Moohebati, Mohsen Hassany, Mitra Kasaian, Jamal Etemadzadeh, Mohammad Reza Alavi, Maryam Sadat Behravan, Javad Iran Red Crescent Med J Research Article BACKGROUND: There are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS). OBJECTIVES: The objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population. PATIENTS AND METHODS: This cross-sectional study was conducted among 263 subjects (97 men and 166 women). Patients (n = 128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran). A 12-lead electrocardiograph plus creatine kinase MB (CK-MB) levels were used as the basis for the diagnosis of myocardial ischemia. The control group was selected from age-matched healthy subjects (n = 135). Non-enzymatic kits were used for extraction of DNA from blood samples. Polymerase chain reaction (PCR) was performed to amplify the DNA fragments. For restriction fragment length polymorphism (RFLP) determination, the DdeI enzyme was used to digest the amplified DNA fragments. Statistical analyses were performed using SPSS version 13.0. RESULTS: There was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (P > 0.05). CONCLUSIONS: The AT1R A1166C polymorphism appeared not to be associated with the presence of ACS in the population studied. Kowsar 2016-07-09 /pmc/articles/PMC5292135/ /pubmed/28191332 http://dx.doi.org/10.5812/ircmj.23942 Text en Copyright © 2016, Iranian Red Crescent Medical Journal http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Delshad, Navid Ghayour-Mobarhan, Majid Mirzaei, Hamed Razavi-Azarkhiavi, Kamal Moohebati, Mohsen Hassany, Mitra Kasaian, Jamal Etemadzadeh, Mohammad Reza Alavi, Maryam Sadat Behravan, Javad Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title | Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title_full | Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title_fullStr | Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title_full_unstemmed | Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title_short | Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population |
title_sort | angiotensin ii type 1 receptor gene a1166c polymorphism was not associated with acute coronary syndrome in an iranian population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292135/ https://www.ncbi.nlm.nih.gov/pubmed/28191332 http://dx.doi.org/10.5812/ircmj.23942 |
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