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Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease

BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. METHODS: The Preferred Reporting Items for Systematic Reviews and Met...

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Autores principales: Zhang, Jia, Xu, Chuan-Ying, Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292147/
https://www.ncbi.nlm.nih.gov/pubmed/28160778
http://dx.doi.org/10.1186/s12883-017-0795-4
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author Zhang, Jia
Xu, Chuan-Ying
Liu, Jun
author_facet Zhang, Jia
Xu, Chuan-Ying
Liu, Jun
author_sort Zhang, Jia
collection PubMed
description BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases. All studies were published before August 3(rd), 2016. Eligible studies were those that reported a prevalence of RBD symptoms among newly diagnosed PD and health control. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by random-effected models. Heterogeneity across studies was assessed using Cochran Q and I(2) statistics. RESULTS: We identified eight studies including 2462 PD patients and 3818 health controls. The overall prevalence of RBD symptoms in PD was 582/2462 (23.6%) compared to 131/3818 (3.4%) in control. And the pooled OR was 5.69 (95% CI 3.60 to 9.00; p = 0.001) with a moderate heterogeneity I(2) = 70.5%. After excluding the study of low weight, the overall polled OR was 3.54 (95% CI 2.77 to 4.52; p < 0.00001) and the heterogeneity was completely eliminated (I(2) = 0%). CONCLUSIONS: RBD symptoms are common non-motor symptoms of PD, and people with PD are at a higher risk of developing RBD. Further studies are needed to understand the natural history of RBD symptoms in PD and its etiological and clinical implications.
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spelling pubmed-52921472017-02-07 Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease Zhang, Jia Xu, Chuan-Ying Liu, Jun BMC Neurol Research Article BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases. All studies were published before August 3(rd), 2016. Eligible studies were those that reported a prevalence of RBD symptoms among newly diagnosed PD and health control. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by random-effected models. Heterogeneity across studies was assessed using Cochran Q and I(2) statistics. RESULTS: We identified eight studies including 2462 PD patients and 3818 health controls. The overall prevalence of RBD symptoms in PD was 582/2462 (23.6%) compared to 131/3818 (3.4%) in control. And the pooled OR was 5.69 (95% CI 3.60 to 9.00; p = 0.001) with a moderate heterogeneity I(2) = 70.5%. After excluding the study of low weight, the overall polled OR was 3.54 (95% CI 2.77 to 4.52; p < 0.00001) and the heterogeneity was completely eliminated (I(2) = 0%). CONCLUSIONS: RBD symptoms are common non-motor symptoms of PD, and people with PD are at a higher risk of developing RBD. Further studies are needed to understand the natural history of RBD symptoms in PD and its etiological and clinical implications. BioMed Central 2017-02-04 /pmc/articles/PMC5292147/ /pubmed/28160778 http://dx.doi.org/10.1186/s12883-017-0795-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Jia
Xu, Chuan-Ying
Liu, Jun
Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title_full Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title_fullStr Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title_full_unstemmed Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title_short Meta-analysis on the prevalence of REM sleep behavior disorder symptoms in Parkinson’s disease
title_sort meta-analysis on the prevalence of rem sleep behavior disorder symptoms in parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292147/
https://www.ncbi.nlm.nih.gov/pubmed/28160778
http://dx.doi.org/10.1186/s12883-017-0795-4
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