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Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept
Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diag...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292165/ https://www.ncbi.nlm.nih.gov/pubmed/28203260 http://dx.doi.org/10.1155/2017/7063859 |
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author | Zhu, Yan-juan Zhang, Hai-bo Liu, Li-rong Liu, Yi-hong Zhang, Fu-li Bai, Jian-ping Li, Yong Qu, Yan-chun Qu, Xin Chen, Xian Li, Yan Luo, Shu-yi Ou, Ai-hua |
author_facet | Zhu, Yan-juan Zhang, Hai-bo Liu, Li-rong Liu, Yi-hong Zhang, Fu-li Bai, Jian-ping Li, Yong Qu, Yan-chun Qu, Xin Chen, Xian Li, Yan Luo, Shu-yi Ou, Ai-hua |
author_sort | Zhu, Yan-juan |
collection | PubMed |
description | Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between the EGFR gene status, YH or YC syndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had their EGFR gene tested, 45.24% YC (76/168) and 25.95% YH (34/131) patients had EGFR mutations (p = 0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar to YC, whereas 160 group B patients were similar to YH. In the 281 patients with EGFR tested, 45.67% group A (58/127) and 28.57% group B patients (44/154) had EGFR mutations (p = 0.003). The EGFR status was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients with YC were more likely to have EGFR gene mutations. |
format | Online Article Text |
id | pubmed-5292165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-52921652017-02-15 Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept Zhu, Yan-juan Zhang, Hai-bo Liu, Li-rong Liu, Yi-hong Zhang, Fu-li Bai, Jian-ping Li, Yong Qu, Yan-chun Qu, Xin Chen, Xian Li, Yan Luo, Shu-yi Ou, Ai-hua Evid Based Complement Alternat Med Research Article Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. The relationships between the EGFR gene status, YH or YC syndrome types, and classification by cluster analysis were analyzed using the chi-square test and multivariate logistic regression. In the 299 patients who had their EGFR gene tested, 45.24% YC (76/168) and 25.95% YH (34/131) patients had EGFR mutations (p = 0.001). Among the 292 patients entered into the cluster analysis, 132 were classified into group A, with signs and symptoms similar to YC, whereas 160 group B patients were similar to YH. In the 281 patients with EGFR tested, 45.67% group A (58/127) and 28.57% group B patients (44/154) had EGFR mutations (p = 0.003). The EGFR status was independently correlated with TCM syndrome type and classification by cluster analysis on multivariate logistic regression. NSCLC patients with YC were more likely to have EGFR gene mutations. Hindawi Publishing Corporation 2017 2017-01-22 /pmc/articles/PMC5292165/ /pubmed/28203260 http://dx.doi.org/10.1155/2017/7063859 Text en Copyright © 2017 Yan-juan Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhu, Yan-juan Zhang, Hai-bo Liu, Li-rong Liu, Yi-hong Zhang, Fu-li Bai, Jian-ping Li, Yong Qu, Yan-chun Qu, Xin Chen, Xian Li, Yan Luo, Shu-yi Ou, Ai-hua Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title |
Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title_full |
Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title_fullStr |
Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title_full_unstemmed |
Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title_short |
Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept |
title_sort | yin-cold or yang-heat syndrome type of traditional chinese medicine was associated with the epidermal growth factor receptor gene status in non-small cell lung cancer patients: confirmation of a tcm concept |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292165/ https://www.ncbi.nlm.nih.gov/pubmed/28203260 http://dx.doi.org/10.1155/2017/7063859 |
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