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Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity
AIM: To investigate the role of non-structural open reading frame 1 “Y-domain” sequences in the hepatitis E virus (HEV) life cycle. METHODS: Sequences of human HEV Y-domain (amino acid sequences 216-442) and closely-related viruses were analyzed in silico. Site-directed mutagenesis of the Y-domain (...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Baishideng Publishing Group Inc
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292332/ https://www.ncbi.nlm.nih.gov/pubmed/28216965 http://dx.doi.org/10.3748/wjg.v23.i4.590 |