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Enterovirus 71 infection and vaccines

Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising...

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Autores principales: Yi, Eun-Je, Shin, Yun-Ju, Kim, Jeong-Hwan, Kim, Tae-Gyun, Chang, Sun-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292356/
https://www.ncbi.nlm.nih.gov/pubmed/28168168
http://dx.doi.org/10.7774/cevr.2017.6.1.4
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author Yi, Eun-Je
Shin, Yun-Ju
Kim, Jeong-Hwan
Kim, Tae-Gyun
Chang, Sun-Young
author_facet Yi, Eun-Je
Shin, Yun-Ju
Kim, Jeong-Hwan
Kim, Tae-Gyun
Chang, Sun-Young
author_sort Yi, Eun-Je
collection PubMed
description Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal. HFMD is most commonly caused by infection with coxsackievirus A16, and secondly by enterovirus 71 (EV71). Many other strains of coxsackievirus and enterovirus can also cause HFMD. Importantly, HFMD caused by EV71 tends to be associated with fatal complications. Therefore, there is an urgent need to protect against EV71 infection. Development of vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks. Here, we summarize EV71 infection and development of vaccines, focusing on current scientific and clinical progress.
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spelling pubmed-52923562017-02-06 Enterovirus 71 infection and vaccines Yi, Eun-Je Shin, Yun-Ju Kim, Jeong-Hwan Kim, Tae-Gyun Chang, Sun-Young Clin Exp Vaccine Res Review Article Hand, foot and mouth disease (HFMD) is a highly contagious viral infection affecting young children during the spring to fall seasons. Recently, serious outbreaks of HFMD were reported frequently in the Asia-Pacific region, including China and Korea. The symptoms of HFMD are usually mild, comprising fever, loss of appetite, and a rash with blisters, which do not need specific treatment. However, there are uncommon neurological or cardiac complications such as meningitis and acute flaccid paralysis that can be fatal. HFMD is most commonly caused by infection with coxsackievirus A16, and secondly by enterovirus 71 (EV71). Many other strains of coxsackievirus and enterovirus can also cause HFMD. Importantly, HFMD caused by EV71 tends to be associated with fatal complications. Therefore, there is an urgent need to protect against EV71 infection. Development of vaccines against EV71 would be the most effective approach to prevent EV71 outbreaks. Here, we summarize EV71 infection and development of vaccines, focusing on current scientific and clinical progress. The Korean Vaccine Society 2017-01 2017-01-25 /pmc/articles/PMC5292356/ /pubmed/28168168 http://dx.doi.org/10.7774/cevr.2017.6.1.4 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yi, Eun-Je
Shin, Yun-Ju
Kim, Jeong-Hwan
Kim, Tae-Gyun
Chang, Sun-Young
Enterovirus 71 infection and vaccines
title Enterovirus 71 infection and vaccines
title_full Enterovirus 71 infection and vaccines
title_fullStr Enterovirus 71 infection and vaccines
title_full_unstemmed Enterovirus 71 infection and vaccines
title_short Enterovirus 71 infection and vaccines
title_sort enterovirus 71 infection and vaccines
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292356/
https://www.ncbi.nlm.nih.gov/pubmed/28168168
http://dx.doi.org/10.7774/cevr.2017.6.1.4
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