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Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task

Apolipoprotein-E4 (APOE-E4) is a major genetic risk factor for developing Alzheimer’s disease (AD). The verbal fluency task (VFT), especially the subtask category fluency, has shown to provide a good discrimination between cognitively normal controls and subjects with AD. Interestingly, APOE-E4 seem...

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Autores principales: Katzorke, Andrea, Zeller, Julia B. M., Müller, Laura D., Lauer, Martin, Polak, Thomas, Reif, Andreas, Deckert, Jürgen, Herrmann, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292419/
https://www.ncbi.nlm.nih.gov/pubmed/28220068
http://dx.doi.org/10.3389/fnhum.2017.00046
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author Katzorke, Andrea
Zeller, Julia B. M.
Müller, Laura D.
Lauer, Martin
Polak, Thomas
Reif, Andreas
Deckert, Jürgen
Herrmann, Martin J.
author_facet Katzorke, Andrea
Zeller, Julia B. M.
Müller, Laura D.
Lauer, Martin
Polak, Thomas
Reif, Andreas
Deckert, Jürgen
Herrmann, Martin J.
author_sort Katzorke, Andrea
collection PubMed
description Apolipoprotein-E4 (APOE-E4) is a major genetic risk factor for developing Alzheimer’s disease (AD). The verbal fluency task (VFT), especially the subtask category fluency, has shown to provide a good discrimination between cognitively normal controls and subjects with AD. Interestingly, APOE-E4 seems to have no effect on the behavioral performance during a VFT in healthy elderly. Thus, the purpose of the present study was to reveal possible compensation mechanisms by investigating the effect of APOE-E4 on the hemodynamic response in non-demented elderly during a VFT by using functional near-infrared spectroscopy (fNIRS). We compared performance and hemodynamic response of high risk APOE-E4/E4, -E3/E4 carriers with neutral APOE-E3/E3 non-demented subjects (N = 288; 70–77 years). No difference in performance was found. APOE-E4/E4, -E3/E4 carriers had a decreased hemodynamic response in the right inferior frontal junction (IFJ) with a corresponding higher response in the left middle frontal gyrus (MFG) during category fluency. Performance was correlated with the hemodynamic response in the MFG. We assume a compensation of decreased IFJ brain activation by utilizing the MFG during category fluency and thus resulting in no behavioral differences between APOE-groups during the performance of a VFT.
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spelling pubmed-52924192017-02-20 Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task Katzorke, Andrea Zeller, Julia B. M. Müller, Laura D. Lauer, Martin Polak, Thomas Reif, Andreas Deckert, Jürgen Herrmann, Martin J. Front Hum Neurosci Neuroscience Apolipoprotein-E4 (APOE-E4) is a major genetic risk factor for developing Alzheimer’s disease (AD). The verbal fluency task (VFT), especially the subtask category fluency, has shown to provide a good discrimination between cognitively normal controls and subjects with AD. Interestingly, APOE-E4 seems to have no effect on the behavioral performance during a VFT in healthy elderly. Thus, the purpose of the present study was to reveal possible compensation mechanisms by investigating the effect of APOE-E4 on the hemodynamic response in non-demented elderly during a VFT by using functional near-infrared spectroscopy (fNIRS). We compared performance and hemodynamic response of high risk APOE-E4/E4, -E3/E4 carriers with neutral APOE-E3/E3 non-demented subjects (N = 288; 70–77 years). No difference in performance was found. APOE-E4/E4, -E3/E4 carriers had a decreased hemodynamic response in the right inferior frontal junction (IFJ) with a corresponding higher response in the left middle frontal gyrus (MFG) during category fluency. Performance was correlated with the hemodynamic response in the MFG. We assume a compensation of decreased IFJ brain activation by utilizing the MFG during category fluency and thus resulting in no behavioral differences between APOE-groups during the performance of a VFT. Frontiers Media S.A. 2017-02-06 /pmc/articles/PMC5292419/ /pubmed/28220068 http://dx.doi.org/10.3389/fnhum.2017.00046 Text en Copyright © 2017 Katzorke, Zeller, Müller, Lauer, Polak, Reif, Deckert and Herrmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Katzorke, Andrea
Zeller, Julia B. M.
Müller, Laura D.
Lauer, Martin
Polak, Thomas
Reif, Andreas
Deckert, Jürgen
Herrmann, Martin J.
Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title_full Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title_fullStr Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title_full_unstemmed Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title_short Reduced Activity in the Right Inferior Frontal Gyrus in Elderly APOE-E4 Carriers during a Verbal Fluency Task
title_sort reduced activity in the right inferior frontal gyrus in elderly apoe-e4 carriers during a verbal fluency task
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292419/
https://www.ncbi.nlm.nih.gov/pubmed/28220068
http://dx.doi.org/10.3389/fnhum.2017.00046
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