Absence of an N-Linked Glycosylation Motif in the Glycoprotein of the Live-Attenuated Argentine Hemorrhagic Fever Vaccine, Candid #1, Results in Its Improper Processing, and Reduced Surface Expression

Junin virus (JUNV), a highly pathogenic New World arenavirus, is the causative agent of Argentine hemorrhagic fever (AHF). The live-attenuated Candid #1 (Can) strain currently serves as a vaccine for at-risk populations. We have previously shown that the Can glycoprotein (GPC) gene is the primary ge...

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Detalles Bibliográficos
Autores principales: Manning, John T., Seregin, Alexey V., Yun, Nadezhda E., Koma, Takaaki, Huang, Cheng, Barral, José, de la Torre, Juan C., Paessler, Slobodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292626/
https://www.ncbi.nlm.nih.gov/pubmed/28220142
http://dx.doi.org/10.3389/fcimb.2017.00020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292626/
https://www.ncbi.nlm.nih.gov/pubmed/28220142
http://dx.doi.org/10.3389/fcimb.2017.00020

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