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Isocitrate dehydrogenase mutations in myeloid malignancies

Alterations to genes involved in cellular metabolism and epigenetic regulation are implicated in the pathogenesis of myeloid malignancies. Recurring mutations in isocitrate dehydrogenase (IDH) genes are detected in approximately 20% of adult patients with acute myeloid leukemia (AML) and 5% of adult...

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Detalles Bibliográficos
Autores principales:	Medeiros, B C, Fathi, A T, DiNardo, C D, Pollyea, D A, Chan, S M, Swords, R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292675/ https://www.ncbi.nlm.nih.gov/pubmed/27721426 http://dx.doi.org/10.1038/leu.2016.275

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