Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma

Multiple myeloma (MM), an incurable plasma cell malignancy, requires localisation within the bone marrow. This microenvironment facilitates crucial interactions between the cancer cells and stromal cell types that permit the tumour to survive and proliferate. There is increasing evidence that the bo...

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Detalles Bibliográficos
Autores principales: McNee, G, Eales, K L, Wei, W, Williams, D S, Barkhuizen, A, Bartlett, D B, Essex, S, Anandram, S, Filer, A, Moss, P A H, Pratt, G, Basu, S, Davies, C C, Tennant, D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292682/
https://www.ncbi.nlm.nih.gov/pubmed/27400413
http://dx.doi.org/10.1038/leu.2016.187

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