A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

We developed a novel murine monoclonal antibody (mAb) against the C-terminal α-helix of the human von Willebrand factor A2, designated SZ-179. We showed that SZ-179 inhibited the interactions between VWF and ADAMTS13 and prevented the degradation of high molecular weight VWF multimers. Importantly,...

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Detalles Bibliográficos
Autores principales: Zhang, Lulu, Su, Jian, Shen, Fei, Ma, Zhenni, Zhao, Yiming, Xia, Lijun, Ruan, Changgeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292787/
https://www.ncbi.nlm.nih.gov/pubmed/28166803
http://dx.doi.org/10.1186/s13045-017-0407-1

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