Cargando…
Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium
BACKGROUND: Utilities and disability weights (DWs) are metrics used for calculating Quality-Adjusted Life Years and Disability-Adjusted Life Years (DALYs), respectively. Utilities can be obtained with multi-attribute instruments such as the EuroQol 5 dimensions questionnaire (EQ-5D). In 2010 and 201...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292789/ https://www.ncbi.nlm.nih.gov/pubmed/28191312 http://dx.doi.org/10.1186/s13690-017-0174-z |
_version_ | 1782504990420500480 |
---|---|
author | Maertens de Noordhout, C. Devleesschauwer, B. Gielens, L. Plasmans, M. H. D. Haagsma, J. A. Speybroeck, N. |
author_facet | Maertens de Noordhout, C. Devleesschauwer, B. Gielens, L. Plasmans, M. H. D. Haagsma, J. A. Speybroeck, N. |
author_sort | Maertens de Noordhout, C. |
collection | PubMed |
description | BACKGROUND: Utilities and disability weights (DWs) are metrics used for calculating Quality-Adjusted Life Years and Disability-Adjusted Life Years (DALYs), respectively. Utilities can be obtained with multi-attribute instruments such as the EuroQol 5 dimensions questionnaire (EQ-5D). In 2010 and 2013, Salomon et al. proposed a set of DWs for 220 and 183 health states, respectively. The objective of this study is to develop an approach for mapping EQ-5D utilities to existing GBD 2010 and GBD 2013 DWs, allowing to predict new GBD 2010/2013 DWs based on EQ-5D utilities. METHODS: We conducted two pilot studies including respectively four and twenty-seven health states selected from the 220 DWs of the GBD 2010 study. In the first study, each participant evaluated four health conditions using the standard written EQ-5D-5 L questionnaire. In the second study, each participant evaluated four health conditions randomly selected among the twenty-seven health states using a previously developed web-based EQ-5D-5 L questionnaire. The EQ-5D responses were translated into utilities using the model developed by Cleemput et al. A loess regression allowed to map EQ-5D utilities to logit transformed DWs. RESULTS: Overall, 81 and 393 respondents completed the first and the second survey, respectively. In the first study, a monotonic relationship between derived utilities and predicted GBD 2010/2013 DWs was observed, but not in the second study. There were some important differences in ranking of health states based on utilities versus GBD 2010/2013 DWs. The participants of the current study attributed a relatively higher severity level to musculoskeletal disorders such as ‘Amputation of both legs’ and a relatively lower severity level to non-functional disorders such as ‘Headache migraine’ compared to the participants of the GBD 2010/2013 studies. CONCLUSION: This study suggests the possibility to translate any utility derived from EQ-5D scores into a DW, but also highlights important caveats. We observed a satisfactory result of this methodology when utilities were derived from a population of public health students, a written questionnaire and a small number of health states in the presence of a study leader. However the results were unsatisfactory when utilities were derived from a sample of the general population, using a web-based questionnaire. We recommend to repeat the study in a larger and more diverse sample to obtain a more representative distribution of educational level and age. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13690-017-0174-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5292789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52927892017-02-10 Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium Maertens de Noordhout, C. Devleesschauwer, B. Gielens, L. Plasmans, M. H. D. Haagsma, J. A. Speybroeck, N. Arch Public Health Research BACKGROUND: Utilities and disability weights (DWs) are metrics used for calculating Quality-Adjusted Life Years and Disability-Adjusted Life Years (DALYs), respectively. Utilities can be obtained with multi-attribute instruments such as the EuroQol 5 dimensions questionnaire (EQ-5D). In 2010 and 2013, Salomon et al. proposed a set of DWs for 220 and 183 health states, respectively. The objective of this study is to develop an approach for mapping EQ-5D utilities to existing GBD 2010 and GBD 2013 DWs, allowing to predict new GBD 2010/2013 DWs based on EQ-5D utilities. METHODS: We conducted two pilot studies including respectively four and twenty-seven health states selected from the 220 DWs of the GBD 2010 study. In the first study, each participant evaluated four health conditions using the standard written EQ-5D-5 L questionnaire. In the second study, each participant evaluated four health conditions randomly selected among the twenty-seven health states using a previously developed web-based EQ-5D-5 L questionnaire. The EQ-5D responses were translated into utilities using the model developed by Cleemput et al. A loess regression allowed to map EQ-5D utilities to logit transformed DWs. RESULTS: Overall, 81 and 393 respondents completed the first and the second survey, respectively. In the first study, a monotonic relationship between derived utilities and predicted GBD 2010/2013 DWs was observed, but not in the second study. There were some important differences in ranking of health states based on utilities versus GBD 2010/2013 DWs. The participants of the current study attributed a relatively higher severity level to musculoskeletal disorders such as ‘Amputation of both legs’ and a relatively lower severity level to non-functional disorders such as ‘Headache migraine’ compared to the participants of the GBD 2010/2013 studies. CONCLUSION: This study suggests the possibility to translate any utility derived from EQ-5D scores into a DW, but also highlights important caveats. We observed a satisfactory result of this methodology when utilities were derived from a population of public health students, a written questionnaire and a small number of health states in the presence of a study leader. However the results were unsatisfactory when utilities were derived from a sample of the general population, using a web-based questionnaire. We recommend to repeat the study in a larger and more diverse sample to obtain a more representative distribution of educational level and age. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13690-017-0174-z) contains supplementary material, which is available to authorized users. BioMed Central 2017-02-06 /pmc/articles/PMC5292789/ /pubmed/28191312 http://dx.doi.org/10.1186/s13690-017-0174-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Maertens de Noordhout, C. Devleesschauwer, B. Gielens, L. Plasmans, M. H. D. Haagsma, J. A. Speybroeck, N. Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title | Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title_full | Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title_fullStr | Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title_full_unstemmed | Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title_short | Mapping EQ-5D utilities to GBD 2010 and GBD 2013 disability weights: results of two pilot studies in Belgium |
title_sort | mapping eq-5d utilities to gbd 2010 and gbd 2013 disability weights: results of two pilot studies in belgium |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292789/ https://www.ncbi.nlm.nih.gov/pubmed/28191312 http://dx.doi.org/10.1186/s13690-017-0174-z |
work_keys_str_mv | AT maertensdenoordhoutc mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium AT devleesschauwerb mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium AT gielensl mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium AT plasmansmhd mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium AT haagsmaja mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium AT speybroeckn mappingeq5dutilitiestogbd2010andgbd2013disabilityweightsresultsoftwopilotstudiesinbelgium |