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Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects

BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose...

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Autores principales: Yoshizane, Chiyo, Mizote, Akiko, Yamada, Mika, Arai, Norie, Arai, Shigeyuki, Maruta, Kazuhiko, Mitsuzumi, Hitoshi, Ariyasu, Toshio, Ushio, Shimpei, Fukuda, Shigeharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292800/
https://www.ncbi.nlm.nih.gov/pubmed/28166771
http://dx.doi.org/10.1186/s12937-017-0233-x
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author Yoshizane, Chiyo
Mizote, Akiko
Yamada, Mika
Arai, Norie
Arai, Shigeyuki
Maruta, Kazuhiko
Mitsuzumi, Hitoshi
Ariyasu, Toshio
Ushio, Shimpei
Fukuda, Shigeharu
author_facet Yoshizane, Chiyo
Mizote, Akiko
Yamada, Mika
Arai, Norie
Arai, Shigeyuki
Maruta, Kazuhiko
Mitsuzumi, Hitoshi
Ariyasu, Toshio
Ushio, Shimpei
Fukuda, Shigeharu
author_sort Yoshizane, Chiyo
collection PubMed
description BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose improved glucose tolerance in human subjects. However, the underlying metabolic responses after trehalose ingestion in humans are not well understood. Therefore, we examined the glycemic, insulinemic and incretin responses after trehalose ingestion in healthy Japanese volunteers. METHODS: In a crossover study, 20 fasted healthy volunteers consumed 25 g trehalose or glucose in 100 mL water. Blood samples were taken frequently over the following 3 h, and blood glucose, insulin, active gastric inhibitory polypeptide (GIP) and active glucagon-like peptide-1 (GLP-1) levels were measured. RESULTS: Trehalose ingestion did not evoke rapid increases in blood glucose levels, and had a lower stimulatory potency of insulin and active GIP secretion compared with glucose ingestion. Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose ingestion as compared with glucose ingestion. Specifically, active GIP secretion, which induces fat accumulation, was markedly lower after trehalose ingestion. CONCLUSIONS: Our findings indicate that trehalose may be a useful saccharide for good health because of properties that do not stimulate rapid increases in blood glucose and excessive secretion of insulin and GIP promoting fat accumulation.
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spelling pubmed-52928002017-02-10 Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects Yoshizane, Chiyo Mizote, Akiko Yamada, Mika Arai, Norie Arai, Shigeyuki Maruta, Kazuhiko Mitsuzumi, Hitoshi Ariyasu, Toshio Ushio, Shimpei Fukuda, Shigeharu Nutr J Short Report BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose improved glucose tolerance in human subjects. However, the underlying metabolic responses after trehalose ingestion in humans are not well understood. Therefore, we examined the glycemic, insulinemic and incretin responses after trehalose ingestion in healthy Japanese volunteers. METHODS: In a crossover study, 20 fasted healthy volunteers consumed 25 g trehalose or glucose in 100 mL water. Blood samples were taken frequently over the following 3 h, and blood glucose, insulin, active gastric inhibitory polypeptide (GIP) and active glucagon-like peptide-1 (GLP-1) levels were measured. RESULTS: Trehalose ingestion did not evoke rapid increases in blood glucose levels, and had a lower stimulatory potency of insulin and active GIP secretion compared with glucose ingestion. Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose ingestion as compared with glucose ingestion. Specifically, active GIP secretion, which induces fat accumulation, was markedly lower after trehalose ingestion. CONCLUSIONS: Our findings indicate that trehalose may be a useful saccharide for good health because of properties that do not stimulate rapid increases in blood glucose and excessive secretion of insulin and GIP promoting fat accumulation. BioMed Central 2017-02-06 /pmc/articles/PMC5292800/ /pubmed/28166771 http://dx.doi.org/10.1186/s12937-017-0233-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Yoshizane, Chiyo
Mizote, Akiko
Yamada, Mika
Arai, Norie
Arai, Shigeyuki
Maruta, Kazuhiko
Mitsuzumi, Hitoshi
Ariyasu, Toshio
Ushio, Shimpei
Fukuda, Shigeharu
Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title_full Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title_fullStr Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title_full_unstemmed Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title_short Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
title_sort glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292800/
https://www.ncbi.nlm.nih.gov/pubmed/28166771
http://dx.doi.org/10.1186/s12937-017-0233-x
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