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Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects
BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292800/ https://www.ncbi.nlm.nih.gov/pubmed/28166771 http://dx.doi.org/10.1186/s12937-017-0233-x |
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author | Yoshizane, Chiyo Mizote, Akiko Yamada, Mika Arai, Norie Arai, Shigeyuki Maruta, Kazuhiko Mitsuzumi, Hitoshi Ariyasu, Toshio Ushio, Shimpei Fukuda, Shigeharu |
author_facet | Yoshizane, Chiyo Mizote, Akiko Yamada, Mika Arai, Norie Arai, Shigeyuki Maruta, Kazuhiko Mitsuzumi, Hitoshi Ariyasu, Toshio Ushio, Shimpei Fukuda, Shigeharu |
author_sort | Yoshizane, Chiyo |
collection | PubMed |
description | BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose improved glucose tolerance in human subjects. However, the underlying metabolic responses after trehalose ingestion in humans are not well understood. Therefore, we examined the glycemic, insulinemic and incretin responses after trehalose ingestion in healthy Japanese volunteers. METHODS: In a crossover study, 20 fasted healthy volunteers consumed 25 g trehalose or glucose in 100 mL water. Blood samples were taken frequently over the following 3 h, and blood glucose, insulin, active gastric inhibitory polypeptide (GIP) and active glucagon-like peptide-1 (GLP-1) levels were measured. RESULTS: Trehalose ingestion did not evoke rapid increases in blood glucose levels, and had a lower stimulatory potency of insulin and active GIP secretion compared with glucose ingestion. Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose ingestion as compared with glucose ingestion. Specifically, active GIP secretion, which induces fat accumulation, was markedly lower after trehalose ingestion. CONCLUSIONS: Our findings indicate that trehalose may be a useful saccharide for good health because of properties that do not stimulate rapid increases in blood glucose and excessive secretion of insulin and GIP promoting fat accumulation. |
format | Online Article Text |
id | pubmed-5292800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-52928002017-02-10 Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects Yoshizane, Chiyo Mizote, Akiko Yamada, Mika Arai, Norie Arai, Shigeyuki Maruta, Kazuhiko Mitsuzumi, Hitoshi Ariyasu, Toshio Ushio, Shimpei Fukuda, Shigeharu Nutr J Short Report BACKGROUND: Trehalose is hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into two glucose molecules. In animal studies, trehalose has been shown to prevent adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat diet. Recently, we found that trehalose improved glucose tolerance in human subjects. However, the underlying metabolic responses after trehalose ingestion in humans are not well understood. Therefore, we examined the glycemic, insulinemic and incretin responses after trehalose ingestion in healthy Japanese volunteers. METHODS: In a crossover study, 20 fasted healthy volunteers consumed 25 g trehalose or glucose in 100 mL water. Blood samples were taken frequently over the following 3 h, and blood glucose, insulin, active gastric inhibitory polypeptide (GIP) and active glucagon-like peptide-1 (GLP-1) levels were measured. RESULTS: Trehalose ingestion did not evoke rapid increases in blood glucose levels, and had a lower stimulatory potency of insulin and active GIP secretion compared with glucose ingestion. Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose ingestion as compared with glucose ingestion. Specifically, active GIP secretion, which induces fat accumulation, was markedly lower after trehalose ingestion. CONCLUSIONS: Our findings indicate that trehalose may be a useful saccharide for good health because of properties that do not stimulate rapid increases in blood glucose and excessive secretion of insulin and GIP promoting fat accumulation. BioMed Central 2017-02-06 /pmc/articles/PMC5292800/ /pubmed/28166771 http://dx.doi.org/10.1186/s12937-017-0233-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Yoshizane, Chiyo Mizote, Akiko Yamada, Mika Arai, Norie Arai, Shigeyuki Maruta, Kazuhiko Mitsuzumi, Hitoshi Ariyasu, Toshio Ushio, Shimpei Fukuda, Shigeharu Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title | Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title_full | Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title_fullStr | Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title_full_unstemmed | Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title_short | Glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
title_sort | glycemic, insulinemic and incretin responses after oral trehalose ingestion in healthy subjects |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292800/ https://www.ncbi.nlm.nih.gov/pubmed/28166771 http://dx.doi.org/10.1186/s12937-017-0233-x |
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