iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers

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One attractive strategy to treat cancers is to deliver an exogenous enzyme that will convert a non-toxic compound to a highly toxic derivative. The strategy was tested with viral vectors but was disappointing because the efficiency of transduction into tumor cells was too low. Recent reports demonst...

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Detalles Bibliográficos
Autores principales: Ullah, M, Kuroda, Y, Bartosh, T J, Liu, F, Zhao, Q, Gregory, C, Reger, R, Xu, J, Lee, R H, Prockop, D J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292869/
https://www.ncbi.nlm.nih.gov/pubmed/28179988
http://dx.doi.org/10.1038/cddiscovery.2016.64
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