Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis

Wnt7a is a protein that plays a critical role in skeletal development. However, its effect on cartilage homeostasis under pathological conditions is not known. In this study, we found a unique inverse correlation between Wnt7a gene expression and that of MMP and IL-1β in individual human OA cartilag...

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Detalles Bibliográficos
Autores principales: Gibson, Averi L., Hui Mingalone, Carrie K., Foote, Andrea T., Uchimura, Tomoya, Zhang, Ming, Zeng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292965/
https://www.ncbi.nlm.nih.gov/pubmed/28165497
http://dx.doi.org/10.1038/srep41823

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