Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

BACKGROUND: Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid hyperplasia. OBJECTIVES: Because regulation of the phosphoinositide 3-kinase (PI3K) pathway is critical for maintaining regulatory T (Treg)...

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Detalles Bibliográficos
Autores principales: Chen, Hannah H., Händel, Norman, Ngeow, Joanne, Muller, James, Hühn, Michael, Yang, Huei-Ting, Heindl, Mario, Berbers, Roos-Marijn, Hegazy, Ahmed N., Kionke, Janina, Yehia, Lamis, Sack, Ulrich, Bläser, Frank, Rensing-Ehl, Anne, Reifenberger, Julia, Keith, Julia, Travis, Simon, Merkenschlager, Andreas, Kiess, Wieland, Wittekind, Christian, Walker, Lisa, Ehl, Stephan, Aretz, Stefan, Dustin, Michael L., Eng, Charis, Powrie, Fiona, Uhlig, Holm H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2017
Materias:
Immune Deficiencies, Infection, and Systemic Immune Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292998/
https://www.ncbi.nlm.nih.gov/pubmed/27477328
http://dx.doi.org/10.1016/j.jaci.2016.03.059

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