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Interactome disassembly during apoptosis occurs independent of caspase cleavage

Protein–protein interaction networks (interactomes) define the functionality of all biological systems. In apoptosis, proteolysis by caspases is thought to initiate disassembly of protein complexes and cell death. Here we used a quantitative proteomics approach, protein correlation profiling (PCP),...

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Detalles Bibliográficos
Autores principales: Scott, Nichollas E, Rogers, Lindsay D, Prudova, Anna, Brown, Nat F, Fortelny, Nikolaus, Overall, Christopher M, Foster, Leonard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293159/
https://www.ncbi.nlm.nih.gov/pubmed/28082348
http://dx.doi.org/10.15252/msb.20167067