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Improving protein-protein interaction prediction using evolutionary information from low-quality MSAs

Evolutionary information stored in multiple sequence alignments (MSAs) has been used to identify the interaction interface of protein complexes, by measuring either co-conservation or co-mutation of amino acid residues across the interface. Recently, maximum entropy related correlated mutation measu...

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Detalles Bibliográficos
Autores principales: Várnai, Csilla, Burkoff, Nikolas S., Wild, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293240/
https://www.ncbi.nlm.nih.gov/pubmed/28166227
http://dx.doi.org/10.1371/journal.pone.0169356