Cargando…

Leucine alleviates dexamethasone-induced suppression of muscle protein synthesis via synergy involvement of mTOR and AMPK pathways

Glucocorticoids (GCs) are negative muscle protein regulators that contribute to the whole-body catabolic state during stress. Mammalian target of rapamycin (mTOR)-signalling pathway, which acts as a central regulator of protein metabolism, can be activated by branched-chain amino acids (BCAA). In th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xiao J., Yang, Xin, Wang, Ru X., Jiao, Hong C., Zhao, Jing P., Song, Zhi G., Lin, Hai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2016
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293580/ https://www.ncbi.nlm.nih.gov/pubmed/27129299 http://dx.doi.org/10.1042/BSR20160096

Ejemplares similares

Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS–AMPK–mTOR axis
por: Li, Ming-yong, et al.
Publicado: (2019)

Dapagliflozin Alleviates Hepatic Steatosis by Restoring Autophagy via the AMPK-mTOR Pathway
por: Li, Liuran, et al.
Publicado: (2021)

Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
por: Xiao, Fei, et al.
Publicado: (2011)

Schizandrin Protects against OGD/R-Induced Neuronal Injury by Suppressing Autophagy: Involvement of the AMPK/mTOR Pathway
por: Wang, Guangyun, et al.
Publicado: (2019)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

Ursolic Acid Inhibits Leucine-Stimulated mTORC1 Signaling by Suppressing mTOR Localization to Lysosome
por: Ou, Xiang, et al.
Publicado: (2014)

Rosiglitazone Mitigates Dexamethasone-Induced Depression in Mice via Modulating Brain Glucose Metabolism and AMPK/mTOR Signaling Pathway
por: Alhaddad, Aisha, et al.
Publicado: (2023)

Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy
por: Qiu, Xiaobo, et al.
Publicado: (2021)

Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
por: Fan, Xiaodi, et al.
Publicado: (2015)

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway
por: Yang, Lei, et al.
Publicado: (2022)

TFEC contributes to cardiac hypertrophy by inhibiting AMPK/mTOR signaling
por: Zhao, Ting, et al.
Publicado: (2021)

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation
por: Smith, Gordon I., et al.
Publicado: (2015)

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway
por: Tang, Haiping, et al.
Publicado: (2016)

Geniposide alleviates non‐alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways
por: Shen, Bingyu, et al.
Publicado: (2020)

2,5-dimethylcelecoxib alleviated NK and T-cell exhaustion in hepatocellular carcinoma via the gastrointestinal microbiota-AMPK-mTOR axis
por: Pan, Banglun, et al.
Publicado: (2023)

Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR-mediated autophagy
por: Zhu, Yunfeng, et al.
Publicado: (2021)

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes
por: Gran, Petra, et al.
Publicado: (2011)

Endocrine responses and acute mTOR pathway phosphorylation to resistance exercise with leucine and whey
por: Lane, MT, et al.
Publicado: (2017)

A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors
por: Yang, Shujie, et al.
Publicado: (2011)

PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling
por: Ma, Ning, et al.
Publicado: (2021)

AMPK-mTOR pathway is involved in glucose-modulated amino acid sensing and utilization in the mammary glands of lactating goats
por: Cai, Jie, et al.
Publicado: (2020)

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK
por: Su, Yuan, et al.
Publicado: (2019)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

Zhuanggu Zhitong Capsule alleviates postmenopausal osteoporosis in ovariectomized rats by regulating autophagy through AMPK/mTOR signaling pathway
por: Men, Zhitao, et al.
Publicado: (2022)

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway
por: Wang, Jin-Feng, et al.
Publicado: (2018)

Enhancing nasopharyngeal carcinoma cell radiosensitivity by suppressing AKT/mTOR via CENP-N knockdown
por: Wu, Li-Zhi, et al.
Publicado: (2023)

Ononin alleviates H(2)O(2)-induced cardiomyocyte apoptosis and improves cardiac function by activating the AMPK/mTOR/autophagy pathway
por: Pan, Rongrong, et al.
Publicado: (2021)

PLCL1 suppresses tumour progression by regulating AMPK/mTOR-mediated autophagy in renal cell carcinoma
por: Pan, Zhou, et al.
Publicado: (2023)

Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
por: Xu, Shengyu, et al.
Publicado: (2020)

Dehydroepiandrosterone alleviates oleic acid-induced lipid metabolism disorders through activation of AMPK-mTOR signal pathway in primary chicken hepatocytes
por: Yao, Yao, et al.
Publicado: (2022)

Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio)
por: Zhu, Qiang-Sheng, et al.
Publicado: (2020)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Phellodendrine promotes autophagy by regulating the AMPK/mTOR pathway and treats ulcerative colitis
por: Su, Shuai, et al.
Publicado: (2021)

TIPE1‐mediated autophagy suppression promotes nasopharyngeal carcinoma cell proliferation via the AMPK/mTOR signalling pathway
por: Liu, Yongliang, et al.
Publicado: (2020)

Esculetin Alleviates Inflammation, Oxidative Stress and Apoptosis in Intestinal Ischemia/Reperfusion Injury via Targeting SIRT3/AMPK/mTOR Signaling and Regulating Autophagy
por: Shen, Xin, et al.
Publicado: (2023)

Duck Tembusu virus induces incomplete autophagy via the ERK/mTOR and AMPK/mTOR signalling pathways to promote viral replication in neuronal cells
por: Wang, Qing, et al.
Publicado: (2023)

Moderate-intensity exercise alleviates pyroptosis by promoting autophagy in osteoarthritis via the P2X7/AMPK/mTOR axis
por: Li, Zihao, et al.
Publicado: (2021)

Thymol Alleviates LPS-Induced Liver Inflammation and Apoptosis by Inhibiting NLRP3 Inflammasome Activation and the AMPK-mTOR-Autophagy Pathway
por: Dou, Xiujing, et al.
Publicado: (2022)

Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling
por: Wang, Da-hua, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ieq5mb505k1hgvttcijlni1t5e