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Molecular Mechanisms in Mood Regulation Involving the Circadian Clock
The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or ch...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293817/ https://www.ncbi.nlm.nih.gov/pubmed/28223962 http://dx.doi.org/10.3389/fneur.2017.00030 |
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author | Albrecht, Urs |
author_facet | Albrecht, Urs |
author_sort | Albrecht, Urs |
collection | PubMed |
description | The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or chronic stress, is correlated with several diseases such as obesity, cancer, and neurological disorders. Molecular mechanisms linking the circadian clock with neurological functions have been uncovered suggesting that disruption of the clock may be critically involved in the development of mood disorders. In this mini-review, I will summarize molecular mechanisms in which clock components play a central role for mood regulation. Such mechanisms have been identified in the monoaminergic system, the HPA axis, and neurogenesis. |
format | Online Article Text |
id | pubmed-5293817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52938172017-02-21 Molecular Mechanisms in Mood Regulation Involving the Circadian Clock Albrecht, Urs Front Neurol Neuroscience The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or chronic stress, is correlated with several diseases such as obesity, cancer, and neurological disorders. Molecular mechanisms linking the circadian clock with neurological functions have been uncovered suggesting that disruption of the clock may be critically involved in the development of mood disorders. In this mini-review, I will summarize molecular mechanisms in which clock components play a central role for mood regulation. Such mechanisms have been identified in the monoaminergic system, the HPA axis, and neurogenesis. Frontiers Media S.A. 2017-02-07 /pmc/articles/PMC5293817/ /pubmed/28223962 http://dx.doi.org/10.3389/fneur.2017.00030 Text en Copyright © 2017 Albrecht. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Albrecht, Urs Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title | Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title_full | Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title_fullStr | Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title_full_unstemmed | Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title_short | Molecular Mechanisms in Mood Regulation Involving the Circadian Clock |
title_sort | molecular mechanisms in mood regulation involving the circadian clock |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293817/ https://www.ncbi.nlm.nih.gov/pubmed/28223962 http://dx.doi.org/10.3389/fneur.2017.00030 |
work_keys_str_mv | AT albrechturs molecularmechanismsinmoodregulationinvolvingthecircadianclock |