Systematic Approach for the Formulation and Optimization of Solid Lipid Nanoparticles of Efavirenz by High Pressure Homogenization Using Design of Experiments for Brain Targeting and Enhanced Bioavailability

The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is repo...

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Detalles Bibliográficos
Autores principales: Gupta, Shweta, Kesarla, Rajesh, Chotai, Narendra, Misra, Ambikanandan, Omri, Abdelwahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294220/
https://www.ncbi.nlm.nih.gov/pubmed/28243600
http://dx.doi.org/10.1155/2017/5984014

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