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Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder

Autism spectrum disorder (ASD) is characterized by deficits in social functioning and language and communication, with restricted interests or stereotyped behaviors. Anatomical differences have been found in the parietal cortex in children with ASD, but parietal subregions and associations between S...

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Autores principales: Knaus, Tracey A., Tager-Flusberg, Helen, Foundas, Anne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294235/
https://www.ncbi.nlm.nih.gov/pubmed/22713374
http://dx.doi.org/10.3233/BEN-2012-110214
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author Knaus, Tracey A.
Tager-Flusberg, Helen
Foundas, Anne L.
author_facet Knaus, Tracey A.
Tager-Flusberg, Helen
Foundas, Anne L.
author_sort Knaus, Tracey A.
collection PubMed
description Autism spectrum disorder (ASD) is characterized by deficits in social functioning and language and communication, with restricted interests or stereotyped behaviors. Anatomical differences have been found in the parietal cortex in children with ASD, but parietal subregions and associations between Sylvian fissure (SF) and parietal anatomy have not been explored. In this study, SF length and anterior and posterior parietal volumes were measured on MRI in 30 right-handed boys with ASD and 30 right-handed typically developing boys (7–14 years), matched on age and non-verbal IQ. There was leftward SF and anterior parietal asymmetry, and rightward posterior parietal asymmetry, across groups. There were associations between SF and parietal asymmetries, with slight group differences. Typical SF asymmetry was associated with typical anterior and posterior parietal asymmetry, in both groups. In the atypical SF asymmetry group, controls had atypical parietal asymmetry, whereas in ASD there were more equal numbers of individuals with typical as atypical anterior parietal asymmetry. We did not find significant anatomical-behavioral associations. Our findings of more individuals in the ASD group having a dissociation between cortical asymmetries warrants further investigation of these subgroups and emphasizes the importance of investigating anatomical relationships in addition to group differences in individual regions.
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spelling pubmed-52942352017-04-02 Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder Knaus, Tracey A. Tager-Flusberg, Helen Foundas, Anne L. Behav Neurol Research Article Autism spectrum disorder (ASD) is characterized by deficits in social functioning and language and communication, with restricted interests or stereotyped behaviors. Anatomical differences have been found in the parietal cortex in children with ASD, but parietal subregions and associations between Sylvian fissure (SF) and parietal anatomy have not been explored. In this study, SF length and anterior and posterior parietal volumes were measured on MRI in 30 right-handed boys with ASD and 30 right-handed typically developing boys (7–14 years), matched on age and non-verbal IQ. There was leftward SF and anterior parietal asymmetry, and rightward posterior parietal asymmetry, across groups. There were associations between SF and parietal asymmetries, with slight group differences. Typical SF asymmetry was associated with typical anterior and posterior parietal asymmetry, in both groups. In the atypical SF asymmetry group, controls had atypical parietal asymmetry, whereas in ASD there were more equal numbers of individuals with typical as atypical anterior parietal asymmetry. We did not find significant anatomical-behavioral associations. Our findings of more individuals in the ASD group having a dissociation between cortical asymmetries warrants further investigation of these subgroups and emphasizes the importance of investigating anatomical relationships in addition to group differences in individual regions. IOS Press 2012 2012-02-15 /pmc/articles/PMC5294235/ /pubmed/22713374 http://dx.doi.org/10.3233/BEN-2012-110214 Text en Copyright © 2012 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Knaus, Tracey A.
Tager-Flusberg, Helen
Foundas, Anne L.
Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title_full Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title_fullStr Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title_full_unstemmed Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title_short Sylvian Fissure and Parietal Anatomy in Children with Autism Spectrum Disorder
title_sort sylvian fissure and parietal anatomy in children with autism spectrum disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294235/
https://www.ncbi.nlm.nih.gov/pubmed/22713374
http://dx.doi.org/10.3233/BEN-2012-110214
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