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Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome

The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitti...

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Autores principales: Panou, Theodora, Mastorodemos, Vasileios, Papadaki, Efrosyni, Simos, Panagiotis G., Plaitakis, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294243/
https://www.ncbi.nlm.nih.gov/pubmed/22713377
http://dx.doi.org/10.3233/BEN-2012-110201
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author Panou, Theodora
Mastorodemos, Vasileios
Papadaki, Efrosyni
Simos, Panagiotis G.
Plaitakis, Andreas
author_facet Panou, Theodora
Mastorodemos, Vasileios
Papadaki, Efrosyni
Simos, Panagiotis G.
Plaitakis, Andreas
author_sort Panou, Theodora
collection PubMed
description The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitting MS (RR-MS) displaying mild disability and to a large cohort of age- and education level-matched healthy volunteers (n = 230). Results showed that both CIS and RR-MS patients evidenced a disproportionate impairment in the immediate and delayed recall of the second (as compared to the first) of two short narratives of the Logical Memory WMS-III subtest, and reduced performance on the Memory for Digits-Forward. Performance of either group on the executive tasks was not impaired, showing evidence of a reversed speed-accuracy trade-off. Illness duration emerged as a significant predictor of memory and executive task performance. Clinical, psychoemotional, and brain imaging findings were also examined as potential correlates of memory deficits and disease progression among CIS patients. These findings may signify early-onset decline of specific cognitive functions in CIS, which merits regular follow-up assessments and monitoring of psychoemotional adaptation and everyday functioning.
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spelling pubmed-52942432017-04-02 Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome Panou, Theodora Mastorodemos, Vasileios Papadaki, Efrosyni Simos, Panagiotis G. Plaitakis, Andreas Behav Neurol Research Article The study investigates primary and secondary verbal memory and motor/executive functions (response inhibition and strategy shifting ability) in multiple sclerosis (MS) patients with clinically isolated syndrome (CIS). We studied 44 CIS patients and compared them to 49 patients with relapsing remitting MS (RR-MS) displaying mild disability and to a large cohort of age- and education level-matched healthy volunteers (n = 230). Results showed that both CIS and RR-MS patients evidenced a disproportionate impairment in the immediate and delayed recall of the second (as compared to the first) of two short narratives of the Logical Memory WMS-III subtest, and reduced performance on the Memory for Digits-Forward. Performance of either group on the executive tasks was not impaired, showing evidence of a reversed speed-accuracy trade-off. Illness duration emerged as a significant predictor of memory and executive task performance. Clinical, psychoemotional, and brain imaging findings were also examined as potential correlates of memory deficits and disease progression among CIS patients. These findings may signify early-onset decline of specific cognitive functions in CIS, which merits regular follow-up assessments and monitoring of psychoemotional adaptation and everyday functioning. IOS Press 2012 2012-02-15 /pmc/articles/PMC5294243/ /pubmed/22713377 http://dx.doi.org/10.3233/BEN-2012-110201 Text en Copyright © 2012 Hindawi Publishing Corporation and the authors. http://creativecommons.org/licenses/by/3.0 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Panou, Theodora
Mastorodemos, Vasileios
Papadaki, Efrosyni
Simos, Panagiotis G.
Plaitakis, Andreas
Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title_full Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title_fullStr Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title_full_unstemmed Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title_short Early Signs of Memory Impairment among Multiple Sclerosis Patients with Clinically Isolated Syndrome
title_sort early signs of memory impairment among multiple sclerosis patients with clinically isolated syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294243/
https://www.ncbi.nlm.nih.gov/pubmed/22713377
http://dx.doi.org/10.3233/BEN-2012-110201
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