Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

TGF-β signaling in liver cells has variant roles in the dynamics of liver diseases, including hepatocellular carcinoma (HCC). We previously found a correlation of high levels of the important endogenous negative TGF-β signaling regulator SMAD7 with better clinical outcome in HCC patients. However, t...

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Detalles Bibliográficos
Autores principales: Feng, T, Dzieran, J, Yuan, X, Dropmann, A, Maass, T, Teufel, A, Marhenke, S, Gaiser, T, Rückert, F, Kleiter, I, Kanzler, S, Ebert, M P, Vogel, A, ten Dijke, P, Dooley, S, Meindl-Beinker, N M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294248/
https://www.ncbi.nlm.nih.gov/pubmed/28134936
http://dx.doi.org/10.1038/oncsis.2016.85

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