Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy

Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase (FAK)-dependent s...

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Detalles Bibliográficos
Autores principales: Xu, B, Lefringhouse, J, Liu, Z, West, D, Baldwin, L A, Ou, C, Chen, L, Napier, D, Chaiswing, L, Brewer, L D, St. Clair, D, Thibault, O, van Nagell, J R, Zhou, B P, Drapkin, R, Huang, J-A, Lu, M L, Ueland, F R, Yang, X H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294249/
https://www.ncbi.nlm.nih.gov/pubmed/28134933
http://dx.doi.org/10.1038/oncsis.2016.86

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